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Separation of nadolol stereoisomers by liquid chromatography using Chiralpak IA chiral stationary phase

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dc.contributor.authorArafah, Rami
dc.contributor.authorRibeiro, António E.
dc.contributor.authorRodrigues, Alírio
dc.contributor.authorPais, Luís S.
dc.date.accessioned2015-10-03T14:43:12Z
dc.date.available2015-10-03T14:43:12Z
dc.date.issued2014
dc.description.abstractThe separation of nadolol stereoisomers on CHIRALPAK® AD at both analytical and preparative scales was recently reported by Ribeiro et al. [1]. CHIRALPAK® AD is an amylose-based chiral stationary phase (CSP) and is produced by physical coating of the chiral polymer on a matrix. However, due to their coated nature, this CSP can only be used with a limited range of solvents such as the polar (e.g. alcohols) or non-polar solvents (e.g. alkanes). Immobilization of a polysaccharide-derivative on the support is an evolutionary strategy to make a CSP compatible with the whole range of organic solvents, which will consequently extend its application scope. CHIRALPAK® IA is a CSP containing amylose 3,5-dimethylphenylcarbamate immobilized onto silica gel [2]. This work will present a complete methodology concerning experimental, modelling and simulation results. Both the CHIRALPAK® AD and CHIRALPAK® IA CSPs will be evaluated using the nadolol stereoisomers separation as case study. The selection of the proper CHIRALPAK® IA/solvent combination for preparative operation will be fully study taking into account a complete screening strategy [3]. Additional results will include the measurement of the chiral mixture solubility’s, equilibrium adsorption data and fixed bed (breakthroughs) experiments. The complete screening will lead to the choice of the better solution for the pseudo-binary separation of the nadolol most retained stereoisomer. Finally, experimental results will be presented for the preparative separation using a Simulated Moving Bed (SMB) pilot unit. The results obtained will be compared with previous published work using the CHIRALPAK® AD adsorbent.pt_PT
dc.identifier.citationArafah, E.; Ribeiro, A.E.; Rodrigues, A.E.; Pais, L.S. (2014). Separation of nadolol stereoisomers by liquid chromatography using Chiralpak IA chiral stationary phase. In XXIV Encontro Nacional da Sociedade Portuguesa de Química. Coimbrapt_PT
dc.identifier.urihttp://hdl.handle.net/10198/12125
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.titleSeparation of nadolol stereoisomers by liquid chromatography using Chiralpak IA chiral stationary phasept_PT
dc.typeconference object
dspace.entity.typePublication
person.familyNameArafah
person.familyNameRibeiro
person.familyNamePais
person.givenNameRami
person.givenNameAntónio E.
person.givenNameLuís S.
person.identifier.ciencia-idAB16-ECBF-B886
person.identifier.ciencia-id3211-D5B0-870D
person.identifier.ciencia-id421E-0CCD-A84F
person.identifier.orcid0000-0002-7743-4988
person.identifier.orcid0000-0003-4569-7887
person.identifier.orcid0000-0002-3000-2862
person.identifier.scopus-author-id57151342900
person.identifier.scopus-author-id23390701300
person.identifier.scopus-author-id6603930478
rcaap.rightsopenAccesspt_PT
rcaap.typeconferenceObjectpt_PT
relation.isAuthorOfPublication3cd4864a-8aa6-46a2-9415-767a7551ee62
relation.isAuthorOfPublication52666376-f100-4407-87ef-dc5df3613761
relation.isAuthorOfPublicationc6d25534-8487-45b1-90af-d350f4e3ac55
relation.isAuthorOfPublication.latestForDiscovery52666376-f100-4407-87ef-dc5df3613761

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