Repository logo
 
Publication

Cosmeceutical properties of phenolic acids and use of microencapsulation to ensure controlled release

2017Conference object Open access
Simple item page
dc.contributor.authorTaofiq, Oludemi
dc.contributor.authorHeleno, Sandrina A.
dc.contributor.authorCalhelha, Ricardo C.
dc.contributor.authorFernandes, Isabel P.
dc.contributor.authorAlves, Maria José
dc.contributor.authorGonzález-Paramás, Ana María
dc.contributor.authorBarros, Lillian
dc.contributor.authorBarreiro, M.F.
dc.contributor.authorFerreira, Isabel C.F.R.
dc.date.accessioned2017-12-21T10:48:01Z
dc.date.available2017-12-21T10:48:01Z
dc.date.issued2017
dc.description.abstractSkin care formulations are designed to exert multifunctional benefits to the skin, promoting the interest on natural bioactive compounds as cosmeceutical ingredients. However, the utilization of such natural ingredients can present constraints related to their stability (e.g. against pH and temperature) being microencapsulation useful to overlap some of these limitations [1]. The present work describes the anti-inflammatory, anti-tyrosinase and antimicrobial activities of phydroxybenzoic, p-coumaric, protocatechuic and cinnamic acids. These compounds were microencapsulated using the atomization/coagulation method with sodium alginate coagulated with calcium chloride. The obtained microspheres were characterized in terms of morphology, particle size distribution, FTIR and encapsulation efficiency. Free and microencapsulated individual compounds were then incorporated into a semi-solid cosmetic base formulation. HPLC-DAD was used to check the presence of the compounds in the formulations. Considering anti-inflammatory activity, p-Coumaric acid presented the lowest EC50 value (152 ± 6 μg/mL) (NO production inhibition), followed by cinnamic acid (180 ± 14 μg/mL), which was also the most active in the anti-tyrosinase assay (EC50 = 310 ± 50 μg/mL). All tested compounds displayed antimicrobial activity against Gram positive and Gram negative bacteria. The microparticles showed spherical morphology, various sizes (20-260 μm) with little agglomeration and a unimodal and bimodal particle size distribution (number and volume, respectively). The encapsulation efficiency was above 50 % in all cases. After incorporation, free compounds still maintained some of its bioactive properties, while the encapsulated forms preserved the bioactivity showing a slow release profile of the compounds. Concluding, this encapsulation procedure provides a suitable alternative to prolong retention of bioactive compounds for subsequent release (sustained release).pt_PT
dc.description.sponsorshipFCT and FEDER under Program PT2020 (POCI-COMPETE2020) (CIMO (UID/AGR/00690/2013) and LA LSRE-LCM (POCI-01-0145-FEDER-006984)). Interreg España-Portugal (project 0377_Iberphenol_6_E) and European Structural and Investment Funds (FEEI) through NORTE 2020 (Project Mobilizador ValorNatural®). Project NORTE-01-0145- FEDER-000006, funded by NORTE 2020 under the PT2020, through FEDER.pt_PT
dc.description.versionN/Apt_PT
dc.identifier.citationTaofiq, Oludemi; Heleno, Sandrina A.; Calhelha, Ricardo; Fernandes, Isabel P.; Alves, Maria José; González-Paramás, Ana M.; Barros, Lillian; Barreiro, M.F.; Ferreira, Isabel C.F.R. (2017). Cosmeceutical properties of phenolic acids and use of microencapsulation to ensure controlled release. In In 10º Encontro Nacional de Cromatografia: livro de resumos. Bragança. ISBN 978-972-745-234-7pt_PT
dc.identifier.isbn978-972-745-234-7
dc.identifier.urihttp://hdl.handle.net/10198/14804
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.titleCosmeceutical properties of phenolic acids and use of microencapsulation to ensure controlled releasept_PT
dc.typeconference object
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FAGR%2F00690%2F2013/PT
oaire.citation.conferencePlaceBragança, Portugalpt_PT
oaire.citation.title10º Encontro Nacional de Cromatografiapt_PT
oaire.fundingStream5876
person.familyNameHeleno
person.familyNameCalhelha
person.familyNameFernandes
person.familyNameAlves
person.familyNameBarros
person.familyNameBarreiro
person.familyNameFerreira
person.givenNameSandrina A.
person.givenNameRicardo C.
person.givenNameIsabel P.
person.givenNameMaria José
person.givenNameLillian
person.givenNameFilomena
person.givenNameIsabel C.F.R.
person.identifier469085
person.identifier144781
person.identifier.ciencia-id8B18-3095-6FC9
person.identifier.ciencia-idF313-E3CE-554E
person.identifier.ciencia-id4D1C-441F-C7F0
person.identifier.ciencia-idD618-B3A9-D312
person.identifier.ciencia-id9616-35CB-D001
person.identifier.ciencia-id3418-47D5-5746
person.identifier.ciencia-id9418-CF95-9919
person.identifier.orcid0000-0001-7224-1098
person.identifier.orcid0000-0002-6801-4578
person.identifier.orcid0000-0002-0069-4503
person.identifier.orcid0000-0001-8506-4393
person.identifier.orcid0000-0002-9050-5189
person.identifier.orcid0000-0002-6844-333X
person.identifier.orcid0000-0003-4910-4882
person.identifier.ridL-5951-2014
person.identifier.ridJ-2172-2014
person.identifier.ridL-1552-2016
person.identifier.ridM-6624-2016
person.identifier.ridJ-3600-2013
person.identifier.ridL-9802-2014
person.identifier.ridE-8500-2013
person.identifier.scopus-author-id30067731800
person.identifier.scopus-author-id6507978333
person.identifier.scopus-author-id26323585300
person.identifier.scopus-author-id16400584800
person.identifier.scopus-author-id35236343600
person.identifier.scopus-author-id57188719717
person.identifier.scopus-author-id36868826600
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typeconferenceObjectpt_PT
relation.isAuthorOfPublicatione89b5bf5-d315-49b6-871e-fa8eb6030676
relation.isAuthorOfPublication2d5d1a41-7561-4a01-871c-b4c97da35053
relation.isAuthorOfPublicationaa1919bb-c35d-4abb-a137-10d998ad4eca
relation.isAuthorOfPublication7850f8c2-8834-4d5a-b4a7-df482abd76d3
relation.isAuthorOfPublication3af07ffe-f914-48ba-a5d5-efcf70fdce01
relation.isAuthorOfPublication0391987c-ba90-488b-839a-153447ce1f0f
relation.isAuthorOfPublicationbd0d1537-2e03-41fb-b27a-140af9c35db8
relation.isAuthorOfPublication.latestForDiscovery3af07ffe-f914-48ba-a5d5-efcf70fdce01
relation.isProjectOfPublicationcfb6e380-87c4-4772-8c2c-76799a53d6df
relation.isProjectOfPublication.latestForDiscoverycfb6e380-87c4-4772-8c2c-76799a53d6df

Files

Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
Poster Nac. 298.pdf
Size:
20.39 MB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.75 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

CIMO - Resumos em Proceedings Não Indexados à WoS/Scopus