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Development of nutraceutical formulations based on the mycelium of Pleurotus ostreatus and Agaricus bisporus

2017Journal article Open access
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dc.contributor.authorCardoso, Rossana V.C.
dc.contributor.authorFernandes, Ângela
dc.contributor.authorOliveira, Beatriz
dc.contributor.authorCalhelha, Ricardo C.
dc.contributor.authorBarros, Lillian
dc.contributor.authorMartins, Anabela
dc.contributor.authorFerreira, Isabel C.F.R.
dc.date.accessioned2018-01-25T10:00:00Z
dc.date.accessioned2018-01-30T15:00:21Z
dc.date.available2018-01-25T10:00:00Z
dc.date.available2018-01-30T15:00:21Z
dc.date.issued2017
dc.description.abstractThe present work is aimed at developing nutraceutical formulations based on the mycelium of Agaricus bisporus and Pleurotus ostreatus, highlighting the potential of in vitro culture as a tool to improve the production of bioactive compounds, namely phenolic acids and ergosterol. The mycelia of both species were cultured in different solid and liquid media in order to compare the growth rate and yielded biomass. Fruiting bodies, mycelia and culture media were compared regarding the antioxidant activity, anti-inflammatory effects in RAW264.7 cells and cytotoxicity in human tumor cell lines and non-tumor porcine liver cells. P. ostreatus mycelia showed higher contents of ergosterol and phenolic compounds, and stronger antioxidant activity than the corresponding fruiting body. P. ostreatus and A. bisporus did not show anti-inflammatory activity, and P. ostreatus was the only one showing cytotoxicity in tumor cell lines. The results show that these mushrooms provide compounds with antioxidant and cytotoxic capacities, with variations among species.pt_PT
dc.description.sponsorshipThe authors are grateful to the Fundação para a Ciência e a Tecnologia (FCT, Portugal) for financial support to CIMO (strategic project PEst-OE/AGR/UI0690/2013) and for L. Barros and R. C. Calhelha contracts.
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationCardoso, Rossana V.C.; Fernandes, Ângela; Oliveira, M. Beatriz P.P.; Calhelha, Ricardo C.; Barros, Lillian; Martins, Anabela; Ferreira, Isabel C.F.R. (2017). Development of nutraceutical formulations based on the mycelium of Pleurotus ostreatus and Agaricus bisporus. Food and Function. ISSN 2042-6496. 8, p. 2155-2164en_EN
dc.identifier.doi10.1039/c7fo00515fpt_PT
dc.identifier.issn2042-6496
dc.identifier.urihttp://hdl.handle.net/10198/15289
dc.language.isoeng
dc.peerreviewedyespt_PT
dc.subjectNutraceutical formulations
dc.subjectPleurotus ostreatus
dc.subjectAgaricus bisporus
dc.titleDevelopment of nutraceutical formulations based on the mycelium of Pleurotus ostreatus and Agaricus bisporusen_EN
dc.typejournal article
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FAGR%2F00690%2F2013/PT
oaire.fundingStream5876
person.familyNameCardoso
person.familyNameFernandes
person.familyNameCalhelha
person.familyNameBarros
person.familyNameMartins
person.familyNameFerreira
person.givenNameRossana V.C.
person.givenNameÂngela
person.givenNameRicardo C.
person.givenNameLillian
person.givenNameAnabela
person.givenNameIsabel C.F.R.
person.identifier469085
person.identifier144781
person.identifier.ciencia-id151B-A0B5-8D80
person.identifier.ciencia-id2015-0434-AE7C
person.identifier.ciencia-idF313-E3CE-554E
person.identifier.ciencia-id9616-35CB-D001
person.identifier.ciencia-id7B18-A810-6B93
person.identifier.ciencia-id9418-CF95-9919
person.identifier.orcid0000-0002-6870-0391
person.identifier.orcid0000-0002-0157-9873
person.identifier.orcid0000-0002-6801-4578
person.identifier.orcid0000-0002-9050-5189
person.identifier.orcid0000-0001-6218-4413
person.identifier.orcid0000-0003-4910-4882
person.identifier.ridJ-2172-2014
person.identifier.ridJ-3600-2013
person.identifier.ridG-5488-2013
person.identifier.ridE-8500-2013
person.identifier.scopus-author-id57194701579
person.identifier.scopus-author-id6507978333
person.identifier.scopus-author-id35236343600
person.identifier.scopus-author-id7203013518
person.identifier.scopus-author-id36868826600
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccessen_EN
rcaap.typearticlept_PT
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