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Development of a new nutraceutical formulation containing microencapsulated polyphenolic extracts from wild Fragaria vesca L. vegetative parts

2015Conference object Open access
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dc.contributor.authorDias, Maria Inês
dc.contributor.authorBarros, Lillian
dc.contributor.authorOliveira, Beatriz
dc.contributor.authorSantos-Buelga, Celestino
dc.contributor.authorBarreiro, M.F.
dc.contributor.authorFerreira, Isabel C.F.R.
dc.date.accessioned2015-11-03T11:35:48Z
dc.date.available2015-11-03T11:35:48Z
dc.date.issued2015
dc.description.abstractThe microencapsulation of bioactive compounds and its applicability in food matrices arises to overcome many problems related with the use of free bioactives [l]. Natural bioactive extracts are increasingly used in this technique due to their synergistic and additive effects that can provide higher beneficiai effects [2]. The vegetative parts of Fragaria vesca L., wild strawberry, are being used as infüsion or decoction for their detoxifying and diuretic properties; the bioactivities reported for this plant could be correlated with the presence of several families of phenolic compounds such as, ellagic acid derivatives, flavonols and flavan 3-ols [3,4]. In the present study, the individual phenolic profile of hydroalcoholic and aqueous extracts ofwild F. vesca vegetative parts was established using HPLC-DAD/ESI-MS, and related to their antioxidant activity evaluated through several in vitro assays. Furthermore, the most bioactive extract, the infüsion form, was protected by microencapsulation through the atomization/coagulation technique using alginate as the wall material. Also, an applicability experiment was developed using k-carrageeaan gelatine as food matrix, in arder to explore new nutraceutical formulations for food applications. The aqueous preparations presented higher antioxidant activity that the hydromethanolic extracts in DPPH scavenging activity, reducing power, p-carotene bleaching inhibition and TBARS inhibition assays. It gave higher content of phenolic compounds, mainly flavonols and flavan-3-ols: (+)-catechin and quercetin 0-glucuronide, respectively, which can be correlated with the higher bioactivity observed m these extracts. The production of microspheres enriched with the infusion form of wild F. vesca was achieved with success using the atomization/coagulation techaique. The microspheres obtained showed, after FTIR analysis, the desired shape and size. The HPLC-DAD analysis of the coagulation water evidenced encapsulation efficiency dose to 95%. For the incorporation into the gelatme food matrix, high temperatures were used (dissolution of the k-carrageenan), but without affecting the shape and size ofthe enriched microspheres, preserving the bioactive extract. The antioxidant properties of the extract were preserved after microencapsulation, when compared with the free form that loses activity when incorporated in the gelatine matrix without protection. This is an innovative study on the development of nutraceuticals based on F. vesca extracts. Further studies will be required to establish a controlled release ofthe bioactive extract within the organism, using an in vitro gastrointestinal model.pt_PT
dc.identifier.citationDias, Maria Inês; Barros, Lillian; Oliveira, M.B.P.P.; Santos-Buelga, Celestino; Barreiro, M.F.; Ferreira, Isabel C.F.R. (2015). Development of a new nutraceutical formulation containing microencapsulated polyphenolic extracts from wild Fragaria vesca L. vegetative parts. In 5th MoniQA International Conference 2015. Portopt_PT
dc.identifier.isbn978-3-9504109-0-7
dc.identifier.urihttp://hdl.handle.net/10198/12246
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.relationNORTE-07-0162-FEDER-000050pt_PT
dc.relationNORTE-07-0124-FEDER-000014pt_PT
dc.relationIMPROVING SECONDARY METABOLITES PRODUCTION THROUGH IN VITRO CULTURE TECHNIQUE: CHEMICAL AND GENETIC CHARACTERIZATION OF EDIBLE PLANTS, BIOACTIVE PROPERTIES AND MICROENCAPSULATION OF PHENOLIC FRACTIONS
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.titleDevelopment of a new nutraceutical formulation containing microencapsulated polyphenolic extracts from wild Fragaria vesca L. vegetative partspt_PT
dc.typeconference object
dspace.entity.typePublication
oaire.awardTitleIMPROVING SECONDARY METABOLITES PRODUCTION THROUGH IN VITRO CULTURE TECHNIQUE: CHEMICAL AND GENETIC CHARACTERIZATION OF EDIBLE PLANTS, BIOACTIVE PROPERTIES AND MICROENCAPSULATION OF PHENOLIC FRACTIONS
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FEQU%2F50020%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/PEst-OE%2FAGR%2FUI0690%2F2014/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/Incentivo%2FEQB%2FLA0006%2F2014/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F84485%2F2012/PT
oaire.citation.conferencePlacePortopt_PT
oaire.citation.title5th MoniQA International Conference 2015pt_PT
oaire.fundingStream5876
oaire.fundingStream5876
oaire.fundingStream3599-PPCDT
person.familyNameDias
person.familyNameBarros
person.familyNameBarreiro
person.familyNameFerreira
person.givenNameMaria Inês
person.givenNameLillian
person.givenNameFilomena
person.givenNameIsabel C.F.R.
person.identifier469085
person.identifier144781
person.identifier.ciencia-id2A13-4BE6-C7CF
person.identifier.ciencia-id9616-35CB-D001
person.identifier.ciencia-id3418-47D5-5746
person.identifier.ciencia-id9418-CF95-9919
person.identifier.orcid0000-0001-8744-7814
person.identifier.orcid0000-0002-9050-5189
person.identifier.orcid0000-0002-6844-333X
person.identifier.orcid0000-0003-4910-4882
person.identifier.ridM-8242-2013
person.identifier.ridJ-3600-2013
person.identifier.ridL-9802-2014
person.identifier.ridE-8500-2013
person.identifier.scopus-author-id54388787000
person.identifier.scopus-author-id35236343600
person.identifier.scopus-author-id57188719717
person.identifier.scopus-author-id36868826600
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typeconferenceObjectpt_PT
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