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Projeto de investigação
Chemistry Research Unit of University of Porto
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The impact of oligomeric anions on the speciation of protic ionic liquids
Publication . Martins, Mónia A.R.; Carvalho, Pedro J.; Santos, Luís M.N.B.F.; Pinho, Simão; Coutinho, João A.P.
The synthesis of protic ionic liquids based in carboxylate anions, too often admitted as being straightforward, is actually challenging and must be carefully addressed. This review discusses the importance of oligomeric anions, in particular those based on carboxylates, in the behavior and nature of protic ionic liquids. There is strong evidence in the literature that the synthesis, and subsequent purification, of protic ionic liquids involving carboxylic acids, leads to structures in the liquid phase with an acid:base proportion different from the expected 1:1 stoichiometry. The formation of the oligomeric anions, mostly dependent on the proton transfer from the Brønsted acid to the Brønsted base, may lead to a higher ionicity that suggests the formation of true ionic liquids. It is here stressed the relevance of deepening the understanding of the interactions between the species and the speciation of the liquid phase, combining experimental and theoretical approaches to establish foundations for insightful advances in the area.
Synthesis of chromone-related pyrazole compounds
Publication . Santos, Clementina M.M.; Silva, Vera L.M.; Silva, Artur
Chromones, six-membered oxygen heterocycles, and pyrazoles, five-membered two-adjacent-nitrogen-containing heterocycles, represent two important classes of biologically active compounds. Certain derivatives of these scaffolds play an important role in medicinal chemistry and have been extensively used as versatile building blocks in organic synthesis. In this context, we will discuss the most relevant advances on the chemistry that involves both chromone and pyrazole rings. The methods reviewed include the synthesis of chromone-pyrazole dyads, synthesis of chromone-pyrazole-fused compounds, and chromones as starting materials in the synthesis of 3(5)-(2-hydroxyaryl)pyrazoles, among others. This review will cover the literature on the chromone and pyrazole dual chemistry and their outcomes in the 21st century.
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Entidade financiadora
Fundação para a Ciência e a Tecnologia
Programa de financiamento
6817 - DCRRNI ID
Número da atribuição
UID/QUI/00081/2013