NOVOS COMPOSTOS POLIFENÓLICOS COM POTENCIAL ACTIVIDADE ANTIONXIDANTE E ANTI-INFLAMATÓRIA

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Synthesis of Novel 1-Aryl-9H-xanthen-9-ones

Publication . Esteves, Cátia; Santos, Clementina M.M.; Brito, Cristela; Silva, Artur; Cavaleiro, José

A novel route for the synthesis of 1-aryl-9H-xanthen-9-ones is reported. This methodology involves the condensation of 2-methylchromone with cinammaldehydes leading to (E,E)-2-(4-arylbuta-1,3-dien-1-yl)-4H-chromen-4-ones. The final step was the electrocyclization and oxidation reactions of the latter compounds, in an one-pot synthesis, giving the desired 1-aryl-9H-xanthen-9-ones.

2011Journal article

Open access