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Browsing CIMO by Field of Science and Technology (FOS) "Ciências Médicas::Medicina Clínica"
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- Bioactivity of honey: phenolic composition, antioxidant trends and carcinoma cell lines effects through digestionPublication . Mutlu, Ceren; Demir, Zeynep; Aylanc, Volkan; Özkan, Aysun; Erbaş, MustafaHoney is not only a food source but also a valuable substance for health and medicine, owing to its complex composition and bioactive properties. However, there is very limited information on the changes in the active compounds of honey during digestion and their antioxidant capacity and effect on cancer cells at the end of digestion. Herein, we investigate the dynamic changes in their bioactive compound composition and antioxidant activity during in vitro gastrointestinal digestion and the effect of digested honey on several cancer cell lines, after determining the antimicrobial and anti-inflammatory effects of mono- and multifloral kinds of honey. The tested raw honey samples exhibited higher anti-inflammatory properties (36 %–80 %) with increasing total phenolic content (78–132 mg GAE/100 g), along with significant antimicrobial activity against E. coli (6–9 mm) and S. aureus (6–14 mm) bacterial species. The findings showed that total phenolic and flavonoid contents increased significantly during digestion, with a peaking value of 258 mg GAE/100 g in the intestinal phase, while TEAC and CUPRAC analysis exhibited variable trends depending on the digestion stage. Moreover, the concentration of compounds such as gallic, syringic, caffeic, p-coumaric, trans-cinnamic acid, and methyl-3,4,5-trihydroxybenzoate identified by HPLC-DAD showed some fluctuations at different stages of digestion. Cyto-toxicity analysis revealed that digested honey samples, particularly those with higher phenolic content, exhibited pronounced antiproliferative effects on cancer cells at higher concentrations, with minimal effects on healthy cells. These findings underscore the importance of honey’s bioactive compounds, their transformation during digestion, and their potential health benefits.
- Correction: Ex situ germination of European acorns: data from 93 batches of 12 Quercus speciesPublication . Medina, María; Reyes-Martín, Marino P.; Levy, Laura; Lázaro-González, Alba; Andivia, Enrique; Annighöfer, Peter; Assaad, Farhah; Bauhus, Jürgen; Benavides, Raquel; Böhlenius, Henrik; Cambria, Vito E.; Carbonero, María D.; Castro, Jorge; Chalatashvili, Akaki; Chiatante, Donato; Cocozza, Claudia; Corticeiro, Sofa; Lazdina, Dagnija; Dato, Giovanbattista De; Sanctis, Michele De; Devetaković, Jovana; Drossler, Lars; Ehrenbergerová, Lenka; Ferus, Peter; Gómez-Aparicio, Lorena; Hampe, Arndt; Hanssen, Kjersti H.; Heinze, Berthold; Jakubowski, Marcin; Jiménez, María N.; Kanjevac, Branko; Keizer, Jan J.; Kerkez-Janković, Ivona; Klisz, Marcin; Kowalkowski, Wojciech; Kremer, Klaus; Kroon, Johan; Montagna, Dario La; Lazarević, Jelena; Lingua, Emanuele; Lucas-Borja, Manuel E.; Łukowski, Adrian; Löf, Magnus; Maia, Paula; Mairota, Paola; Maltoni, Alberto; Mariotti, Barbara; Martiník, Antonín; Marzano, Rafaella; Matías, Luis; Mcclory, Ryan W.; Merino, Manuel; Mondanelli, Lucia; Montagnoli, Antonio; Monteverdi, Maria C.; Moreno-Llorca, Ricardo; Navarro, Francisco B.; Nonić, Marina; Nunes, Luís; Oliet, Juan A.; Patrício, Maria Sameiro; Poduška, Zoran; Popovic, Vladan; Puchałka, Radosław; Rey-Benayas, José M.; Robakowski, Piotr; Sewerniak, Piotr; Szczerba, Marek; Ureña-Lara, Carmen; Vendina, Viktorija; Villar-Salvador, Pedro; Witzell, Johanna; Leverkus, Alexandro B.Following publication of the original article (Medina et al. 2024), the authors identified an error in the funding declaration.
- Efficacy of Olive Leaf Extract in Improving Blood Pressure in Pre‐Hypertensive and Hypertensive Individuals: A Systematic Review and Meta‐AnalysisPublication . Lachovicz, Rebeca; Ferro-Lebres, Vera; Almeida-de-Souza, Juliana; Pereira, José AlbertoAnnually, approximately 10 million deaths are attributed to hypertension, highlighting the critical need for effective treatments beyond conventional medications due to their limitations. Therefore, the aim of this study was to evaluate the impact of Olea europaea L. on blood pressure in adults with prehypertension and hypertension. The search, conducted from November/2022- October/2024 was performed on EBSCO, CABI, CNKI, Cochrane Library, DOAJ, PUBMED, SCOPUS, and WEB OF SCIENCE databases using Hypertension AND Olea europaea L. Eligible studies included those evaluating the effect of Olea europaea L. on systolic/diastolic blood pressure in hypertensive or pre-hypertensive adults. Exclusion criteria were multi-preparation interventions. Data on reference, country, sample, intervention/control details, duration, and differences in systolic and diastolic blood pressure, adverse effects, and medication use were extracted manually. The mean differences, heterogeneity (I2) and quality of the studies were assessed using Review Manager (version 5.4). From 211 found studies, 3 met the eligibility criteria, considering 248 participants analysed. An antihypertensive effect was observed on systolic and diastolic blood pressure in the pre- vs. post-intervention in the global analysis (systolic −6.03 mmHg, 95% CI: [−11.60, −0.46], I2 = 82%, p = 0.03; diastolic −2.38 mmHg, 95% CI: [−4.96, 0.20], I2 = 50%, p = 0.07) and in the sub-analysis that included the studies with the highest dose (1000 mg/day) (systolic−11.45 mmHg, 95% CI:[−13.99, −8.91], I2 = 0%, p ≤ 0.001; diastolic −4.65 mmHg, 95% CI: [−6.56, −2.74], I2 = 0%, p ≤ 0.001). Olive leaf extract (1000 mg/day) may reduce systolic and diastolic blood pressure by −11.45 and −4.65 mmHg, respectively. However, limitations include variable trial quality and exclusion of studies not written in English. Additional comprehensive clinical studies are essential to confirm its efficacy and safety.
- Phytotherapy: A Systematic Review for the Treatment of HypertensionPublication . Lachovicz, Rebeca; Ferro-Lebres, Vera; Almeida-de-Souza, JulianaIntroduction: Approximately 10 million annual deaths may be associated with hypertension. Adverse effects and non-response to pharmacological treatment limit therapy to a significant proportion of patients; hence, treatment alternatives seem necessary. Our objective was to review data about the impact of herbal medicine on reducing blood pressure (BP) in prehypertensive and hypertensive patients. Methods: A systematic review was conducted (PRISMA guidelines), using PUBMED, SCOPUS, and WEB OF SCIENCE databases, without time restriction. The inclusion criteria were randomised controlled trials and quasiexperimental studies in humans focusing antihypertensive effect of phytotherapeutics: Allium sativum, Apium graveolens, Nigella sativa, Panax ginseng, and Hibiscus sabdariffa on BP in adults with prehypertension or hypertension. The exclusion criteria were the usage of combined medicinal plants. Data about systolic and diastolic BP differences before and after phytotherapy were extracted manually and summarised. The risk of bias was assessed using the JBI tool. Results: Forty-five studies were selected (15 A sativum, 4 A graveolens, 4 N sativa, 9 P ginseng, and 13 H sabdariffa). Antihypertensive effect was observed for A sativum systolic and diastolic BP (−18.1/−9 mmHg), A graveolens (−37.9/−15.4 mmHg), N sativa (−11.8/−8.8 mmHg), P ginseng (−17.4/−7.1 mmHg), and H sabdariffa (−61.4/−66.2 mmHg). Discussion/Conclusions: Herbal medicines can reduce high BP levels in prehypertension and hypertension, when used alone or together with lifestyle changes or antihypertensive drugs. Results interpretation is crucial, given the studies quality variation and the discrepancies. More consistent clinical studies in humans are needed to accurately determine efficacy and safety in the treatment of hypertension.