Browsing by Author "Tavares, Fernando"
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- Ficus carica L.: metabolic and biological screening.Publication . Oliveira, Andreia P.; Valentão, Patrícia; Pereira, J.A.; Silva, Branca M.; Tavares, Fernando; Andrade, Paula B.Ficus carica L. is one of the earliest cultivated fruit trees. In this work, metabolite profiling was performed on the leaves, pulps and peels of two Portuguese white varieties of F. carica (Pingo de Mel and Branca Tradicional). Phenolics and organic acids profiles were determined by HPLC/DAD and HPLC/UV, respectively. All samples presented a similar phenolic profile composed by 3-O- and 5-O-caffeoylquinic acids, ferulic acid, quercetin-3-O-glucoside, quercetin-3-O-rutinoside, psoralen and bergapten. 3-O-Caffeoylquinic acid and quercetin-3-O-glucoside are described for the first time in this species. Leaves’ organic acids profile presented oxalic, citric, malic, quinic, shikimic and fumaric acids, while in pulps and peels quinic acid was absent. The antioxidant potential of the different plant parts was checked. All materials exhibited activity against DPPH and nitric oxide radicals in a concentration-dependent way. However, only the leaves presented capacity to scavenge superoxide radical. Leaves were always the most effective part, which seems to be related with phenolics compounds. Additionally, acetylcholinesterase inhibitory capacity was evaluated, but no effect was observed. Antimicrobial potential was also assessed against several bacterial species, although no activity was noticed. This is the first study comparing the chemical composition and biological potential of F. carica pulps, peels and leaves.
- Impact of high‐risk human papilloma virus genotyping in cervical disease in the Northern region of Portugal: real‐world data from regional cervical cancer screening programPublication . Rosário, Andreia; Sousa, Ana Saraiva; Marinho-Dias, Joana; Medeiros, Rui; Lobo, Cláudia; Leça, Luís; Coimbra, Nuno; Tavares, Fernando; Baldaque, Inês; Martins, Maria Gabriela; Monteiro, Paula; Henrique, RuiCervical cancer prevention is based on primary prevention with vaccines againstHuman Papillomavirus (HPV) and secondary prevention by screening with High‐Risk‐HPV (Hr‐HPV) detection. Since 2017, cervical cancer screening in women aged25−60 years has been performed in Portugal using Hr‐HPV detection, followed bycytology in Hr‐HPV‐positive cases. Herein we report the prevalence of Hr‐HPVgenotypes and cytological abnormalities among 462 401 women (mean age:43.73 ± 10.79; median age: 45; range: 24−66 years) that participated in the RegionalCervical Cancer Screening Program of the Northern Region of Portugal, performedbetween August 2016 and December 2021. Overall, we describe a prevalence rateof 12.50% for Hr‐HPV varying from 20.76% at age 25% to 8.32% at age 64. The fivemost common Hr‐HPV genotypes identified were HPV‐68 (16.09%), HPV‐31(15.30%), HPV‐51 (12.96%), HPV‐16 (11.06%), and HPV‐39 (11.01%). Theprevalence of Hr‐HPV included in the nonavalent vaccine (HPV‐9valent) was55.00% ranging from 47.78% to 59.18% across different age groups.
- Recursos naturais para a sustentabilidadePublication . Castro, José Pedro; Tavares, FernandoOs alunos vencedores do Concurso Escolar “Recursos Naturais para a Sustentabilidade”, promovido pela AGA – Associação Geoparque Arouca e Unesco, participaram num seminário, decorrido em Arouca, no qual foram discutidas diversas questões ambientais e decorreu a entrega de prémios relativos a este concurso. Além de assistirem a várias comunicações sobre os recursos naturais, os alunos tiveram oportunidade de apresentarem à audiência o seu projeto.