Browsing by Author "Lucia, Ceres Mattos Della"
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- Blueberry Extract and Resistance Training Prevent Left Ventricular Redox Dysregulation and Pathological Remodeling in Experimental Severe Pulmonary Arterial HypertensionPublication . Leite, Luciano Bernardes; Soares, Leôncio Lopes; Guimarães-Ervilha, Luiz Otávio; Costa, Sebastião Felipe Ferreira; Generoso, Sara Caco dos Lúcio; Xavier, Mirielly Alexia Miranda; Iasbik-Lima, Thainá; Oliveira, Leandro Licursi; Lucia, Ceres Mattos Della; Bianchi, Sara Elis; Bassani, Valquíria Linck; Herter, Flavio Gilberto; Turck, Patrick; Araujo, Alex Sander da Rosa; Forte, Pedro; Reis, Emily Correna Carlo; Machado-Neves, Mariana; Natali, Antônio JoséTo investigate whether the regular administration of blueberry extract and low-intensity resistance exercise training (RT), either alone or in combination, during the development of monocrotaline (MCT)-induced severe pulmonary arterial hypertension (PAH) in rats protect the left ventricle (LV) from redox dysregulation and pathological remodeling. Groups of seven male Wistar rats were formed for the experiment: sedentary control; sedentary hypertensive; sedentary hypertensive blueberry; exercise hypertensive; and exercise hypertensive blueberry. PAH was experimentally induced through a single intraperitoneal administration of MCT at a dose of 60 mg/kg. One day after injection, the blueberry groups started receiving a daily dose of blueberry extract (100 mg/kg) by gavage, while the exercise groups initiated a three-week program of RT (ladder climbing; 15 climbs carrying 60% of maximum load; one session/day; 5 times/week). Echocardiographic evaluations were conducted 23 days after injection, and the rats were euthanized the next day to harvest LV tissue. Separately, blueberry extract and RT mitigated augments in pulmonary artery resistance, LV tissue redox dysregulation (i.e., increased PC levels) and detrimental remodeling (i.e., reduced inflammation), and reductions in ejection fraction (EF) and fractional shortening (FS) caused by PAH. The combination of treatments prevented reductions in EF and FS, along with the development of a D-shaped LV. blueberry extract and moderate-intensity resistance training administered during the development of MCT-induced severe PAH in rats prevented LV redox dysregulation and pathological remodeling, thereby preserving its function.
- Can physical exercise modify intestinal integrity and gut microbiota composition? A systematic review of in vivo studiesPublication . Pereira, Stephanie Michelin Santana; São José, Vinicius Parzanini Brilhante de; Silva, Alessandra da; Martins, Karina Vitoria Cipriana; Leite , Luciano Bernardes; Forte, Pedro; Natali, Antônio José; Martino, Hércia Stampini Duarte; Lucia, Ceres Mattos Della; Bressan, JosefinaThere is little evidence about how physical exercise affects the gut microbiota since studies in the field are relatively recent. Thus, we aimed to systematically review the main effects of regular physical exercise on the intestinal integrity and microbiota composition in animal models, discuss the mechanisms involved, and indicate future directions. Searches for original articles were performed in PubMed/MEDLINE, Scopus, Web of Science, and Embase. A total of 18 studies were selected. These studies suggest that physical exercise has a significant impact on the gut microbiota. Voluntary running increased the thickness of duodenal villi and microbiota diversity but reduced its richness. Low-intensity treadmill running increased the abundance of the phylum Actinobacteria and the family Bifidobacteriaceae, while that of moderate-intensity reduced the Bacteroides/Prevotella ratio. High-intensity swimming and treadmill running altered the gut microbiota, evidenced by beta-diversity, and increased the Shannon and Chao indices but reduced short-chain fatty acids. Resistance exercise increased the Chao index and altered the functionality of the gut microbiota, increasing carbohydrate metabolism and reducing lipid and amino acid metabolism. Thus, regular physical exercise of different intensities and types can modify the gut microbiota, and the exercise benefits appear to be positively associated with training intensity.