Percorrer por autor "Leite, Priscilla G."
A mostrar 1 - 2 de 2
Resultados por página
Opções de ordenação
- Meta-analysis on the Salt Effect on Glycine Solubility Applying Gaussian ProcessesPublication . Piske, Christopher A.; Leite, Priscilla G.; Martins, Mónia A. R.; Ferreira, Olga; Coutinho, João A. P.; Abranches, João Dinis Oliveira; Pinho, SimãoIn aqueous solutions containing electrolytes, ions influence both the solubility and the stability of biomolecules. However, inconsistencies across published data highlight the need for a critical review. To address this, a database was constructed on the solubility of glycine in electrolyte solutions spanning from 1996 to 2024, and the experimental data were critically evaluated. Gaussian Process (GP) models were implemented to analyze, predict, and validate solubility behavior. The GP model successfully captures salting-in and salting-out trends, along with specific ion effects reported in the literature. It also provides predictive uncertainty estimates that help identify potentially inconsistent data points or sets. This uncertainty-based analysis enables the reconciliation of conflicting datasets and helps prioritize new experimental measurements in regions where data are sparse or less reliable. By applying a data-filtering method that removes experimental points falling outside the uncertainty range of the model, the influence of inconsistent values is reduced. This results in a more robust model fit and improved prediction accuracy. Therefore, the GP establishes a quantitative foundation for consolidating the current knowledge on the solubility of glycine in saline solutions, identifying methodological inconsistencies in the literature.
- Solubility studies of trans-cinnamic acid in mixed solventsPublication . Soares, Bruna de Paula; Ferreira, Olga; Leite, Priscilla G.; Pinho, SimãoPhenolic acids are a subclass of phenolic compounds with chemical and biological properties of interest in the pharmaceutical and food industries. The design of their extraction and separation processes includes the knowledge of their thermophysical properties as well as multicomponent solid-liquid equilibria data. For these compounds, even essential solubility data in pure organic solvents and water are scarce. Therefore, in this work, trans-cinnamic acid was chosen as a model compound for which only a few solubility data in pure water and alcohols can be found in the literature [1-3]. The solubility of trans-cinnamic acid in the mixed solvents water + ethanol, and water + methanol was measured, at 298.15 K, using the isothermal shake-flask method and quantitative analysis either by gravimetry or UV spectrophotometry. As can be seen in Fig. 1, the solubility of the acid can significantly increase with the addition of the alcohol, with a more pronounced effect induced by ethanol. In a complementary approach and aiming to search for other methods to increase the aqueous solubility of trans-cinnamic acid, the phase-solubility diagram was determined for systems containing α-cyclodextrin. References [1] J. Li, Z. Zeng, L. Sun, W. Xue, H. Wang, Journal of Chemical and Engineering Data, 61 (2016) 1192−1198. [2] F. Mota, A. Queimada,, S. Pinho, E. Macedo, Industrial and Engineering Chemistry Research, 47 (2008) 5182-5189. [3] Solubilities of Organic Compounds in Organic Solvents, J. Bradley, C. Neylon, R. Guha, A. Williams, B. Hooker, A. Lang, B. Friesen, Open Notebook Science, 2009.