Percorrer por autor "Coimbra, Ana Maria"
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- Biochemical blood parameters: are they effective biomarkers of chronic toxicity?Publication . Fernandes, Conceição; Fontaínhas-Fernandes, A.; Coimbra, Ana Maria; Saavedra, Maria José; Salgado, Maria AntóniaThe use of biomarkers has become attractive and useful for monitoring environmental quality and health of fish inhabiting polluted ecosystems. Among them, plasmatic biochemical parameters could be a promissory indicator of fish health condition. The question that comes up is if plasmatic biochemical levels could be a tool in a long-term evaluation of the fish stress responses.
- Biochemical blood parameters: are they effective biomarkers of chronic toxicity?Publication . Fernandes, Conceição; Fontaínhas-Fernandes, A.; Coimbra, Ana Maria; Saavedra, Maria José; Salgado, Maria AntóniaThe use of biomarkers has become attractive and useful for monitoring environmental quality and health of fish inhabiting polluted ecosystems. Among them, plasmatic biochemical parameters could be a promissory indicator of fish health condition. The question that arises is if these parameters can be applied to chronic toxicity. In this study we investigated the use of plasmatic biochemical parameters as indicators of fish chronic exposure to metals. Mullets (Liza saliens), inhabiting a metal polluted habitat, a small coastal lagoon Esmoriz-Paramos (Northwest coast, Portugal), showed alterations of plasmatic parameters related with Cu and Zn bioaccumulation in tissues. The effect of metals chronic exposure in plasmatic parameters is scarcely studied and this study in a lagoon, where fish are exposed to metals for its life span, enabled a realistic long-term evaluation of the stress responses
- Oxidative stress responses and histological hepatic alterations in barbel, Barbus bocagei, from Vizela river, PortugalPublication . Peixoto, Francisco P.; Carrola, João; Coimbra, Ana Maria; Fernandes, Conceição; Teixeira, Paulo; Coelho, Luís; Conceição, Ivo; Oliveira, Maria Manuel; Fontaínhas-Fernandes, A.Barbel (Barbus bocagei) a common species in Portuguese rivers was studied to assess the impact of water contamination on hepatic oxidative stress response, lipid peroxidation and histology. The Vizela River is a tributary of the Ave River, located in one of the most industrialized areas of Portugal. The oxidative stress biomarkers analyzed included superoxide dismutase, catalase, glutathione S-transferase, glutathione reductase, glucose 6‑phosphate dehydrogenase and xanthine oxidase activities. Levels of reduced glutathione and lipid peroxidation were also evaluated. Except xanthine oxidase activity, that did not show any alteration, all the other enzymatic activities were increased in the liver of barbel captured in the Vizela River when compared with reference barbel. While, no differences were observed for glutathione reductase content, lipid peroxidation was higher in barbel from the Vizela River. Liver histological alterations were determined and their severity scored. Though lymphocyte foci were only observed in Vizela River barbel, macrophage aggregates were also present in reference barbel, although the severity score was higher in Vizela fish. The results of this study show that barbel liver oxidative stress responses, lipid peroxidation and histology are sensitive to the contaminants present in Vizela River water and are valuable biomarkers for monitoring purposes.