Browsing by Author "Ayob, Rhaira Fernanda Casalvara"
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- Pachira aquatica: biological activity and chemical composition of leaves, flowers, and seedsPublication . Rahal, Isabelle Luiz; Dias, Angelica Barbosa; Canonico, Gabriela Catuzo Silva; Vieira, Marisa Cássia de Araújo Bento; Ayob, Rhaira Fernanda Casalvara; Gonçalves, José Eduardo; Colauto, Nelson Barros; Linde, Giani Andrea; Mandim, Filipa; Vaz, Josiana A.; Barros, Lillian; Valle, Juliana Silveira do; Gazim, Zilda CristianiThe chemical composition of Pachira aquatica crude extracts flowers, leaves, and seeds was obtained by UHPLC-ESI/qTOF and GC/MS. The antiproliferative activity was evaluated against the human tumour cell lines AGS (gastric), CaCo-2 (colorectal), MCF-7 (breast), and NCI-H460 (lung). The anti-inflammatory and cellular antioxidant activities were also studied. Flavonoids, phenolic acids, coumarins, and saturated fatty acids were identified in the samples. The concentration of extracts responsible for inhibiting 50% of nitric oxide production ranged from (149 to > 400 µg mL−1). Antiproliferative activity against the tumour cell lines was: AGS (GI50 175 to > 400 µg mL−1), Caco-2 (GI50 215 to > 400 µg mL−1), MCF7 (GI50 232 to > 400 µg mL−1) and NCI-H460 (GI50 208 to > 400 µg mL−1). Cellular antioxidant activity remained between 73% to > 2000%. The selectivity index (SI) ranged from 1.00 to 2.78, indicating low antiproliferative activity.