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Orientador(es)
Resumo(s)
The pharmaceutical industry is now directed to the market of
more safety and efficient drugs, based on single enantiomers. Ketoprofen,
still used as a racemic pharmaceutical drug, belongs to the
profens class, one of the most representative of the non-steroidal
anti-inflammatory drugs. This work presents the chiral separation
of ketoprofen enantiomers by simulated moving bed technology,
using a laboratory scale unit (the FlexSMB-LSRE1) with six columns,
packed with the Chiralpak AD1 stationary phase (20 lm).
A comparative study between a mobile phase composed of a traditional
high hydrocarbon content (10%ethanol=90%n-hexane=0-
.01%TFA) and a strong polar organic composition (100%ethanol=
0.01%TFA) is presented. The study includes the measurement of
the adsorption isotherms, elution, and frontal chromatography
experiments, carried out on a SMB column for both compositions.
The results obtained allowed the prediction and optimization of
the SMB operation. Using pure ethanol as solvent and a racemic
feed concentration of 40 g=L, purities above 98.6% on both outlet
streams were obtained, with a productivity of 3.84 gfeed=(Lbed.hr)
and a solvent consumption of 0.78Lsolvent=gfeed. The results obtained
in the experimental separation of ketoprofen enantiomers by
SMB chromatography indicates that pure ethanol presents
better performances than the classic high hydrocarbon content
composition.
Descrição
Palavras-chave
Letoprofen Preparative chiral separation Simulated moving bed chromatography Solvent composition
Contexto Educativo
Citação
Ribeiro, António E.; Gomes, Pedro Sá; Pais, Luís S.; Rodrigues, Alírio E. (2011): Chiral separation of ketoprofen enantiomers by preparative and simulated moving bed chromatography. Separation Science and Technology. ISSN 0149-6395. 46:11, p. 1726-1739
Editora
Taylor & Francis