Utilize este identificador para referenciar este registo: http://hdl.handle.net/10198/16600
Título: Searching for signatures of selection in Iberian honey bee (Apis mellifera iberiensis) using whole genome sequences
Autor: Henriques, Dora
Wallberg, Andreas
Chávez-Galarza, Julio
Costa, Filipe
Rufino, José
Webster, Mathew
Pinto, M. Alice
Data: 2015
Editora: Universite de Lausanne
Citação: Henriques, Dora; Wallberg, Andreas; Rufino, José; Chávez-Galarza, Julio; Costa, Filipe; Webster, Mathew; Pinto, M. Alice (2015) - Searching for signatures of selection in Iberian honey bee (Apis mellifera iberiensis) using whole genome sequences. In Congress of the European Society for Evolutionary Biology. Lausanne, Switzerland
Resumo: The Iberian Peninsula comprises a diverse set of habitats. It was an important glacial refugium during the Pleistocene and has served as a bridge for populations migrating between Africa and Europe, resulting in a complex mix of ancestry and diversity. The Iberian honey bee (A. m. iberiensis) is no exception and has been the subject of numerous incongruent population genetic surveys. Recent mtDNA and SNP analyses indicate a steep northeastern-southwestern cline of African ancestry along the peninsula, which has been explained by selection. Advances in DNA sequencing technology and computational tools provide unprecedented opportunities to study demography, search for signatures of selection across the genome and illuminate its role in shaping genomic diversity. We used Illumina technology to sequence the whole genomes of 86 Iberian honeybees, collected across three longitudinal transects in the Iberian Peninsula and spanning semi-arid climates in the southeastern peninsula to oceanic in the North-West. The dataset was first analyzed for FST-outliers, CLR (composite-likelihood ratio) and EHH (Extended Haplotype Homozygosity) methods were further deployed to evaluate polymorphisms implicated in local adaptation and possibly in the response to human- mediated environmental changes, including known and novel variants in genes related to behavior, vision, xenobiotic detoxification and immune response.
Peer review: yes
URI: http://hdl.handle.net/10198/16600
Aparece nas colecções:CIMO - Resumos em Proceedings Não Indexados à WoS/Scopus

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