Utilize este identificador para referenciar este registo: http://hdl.handle.net/10198/13350
Título: Anti-inflammatory potential of mushroom extracts and isolated metabolites
Autor: Taofiq, Oludemi
Martins, Anabela
Barreiro, M.F.
Ferreira, Isabel C.F.R.
Palavras-chave: Inflammation
NSAIDs
Mushrooms
Bioactive compounds
Data: 2016
Citação: Taofiq, Oludemi; Martins, Anabela; Barreiro, M.F.; Ferreira, Isabel C.F.R. (2016) - Anti-inflammatory potential of mushroom extracts and isolated metabolites. Trends in Food Science & Technology. ISSN 0924-2244. 50, p. 193-210
Resumo: Background: In the recent years natural resources are being in focus due to their great potential to be exploited in the discovery/development of novel bioactive compounds and, among them, mushrooms can be highlighted as alternative sources of anti-inflammatory agents. Scope and approach: The present review reports the anti-inflammatory activity of mushroom extracts and of their bioactive metabolites involved in this bioactive action. Additionally the most common assays used to evaluate mushrooms anti-inflammatory activity were also reviewed, including in vitro studies in cell lines, as well as in animal models in vivo. Key findings and conclusions: The anti-inflammatory compounds identified in mushrooms include polysaccharides, terpenes, phenolic acids, steroids, fatty acids and other metabolites. Among them, polysaccharides, terpenoids and phenolic compounds seem to be the most important contributors to the anti-inflammatory activity of mushrooms as demonstrated by numerous studies. However, clinical trials need to be conducted in order to confirm the effectiveness of some of these mushroom compounds namely, inhibitors of NF-κB pathway and of cyclooxygenase related with the expression of many inflammatory mediators.
Peer review: yes
URI: http://hdl.handle.net/10198/13350
DOI: 10.1016/j.tifs.2016.02.005
ISSN: 0924-2244
Aparece nas colecções:CIMO - Artigos em Revistas Indexados à WoS/Scopus

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