Orientador(es)
Resumo(s)
Two flavone glycosides, apigenin-6-C-glucoside (1) and lutelin-6-C-glucoside (2), and an anomeric mixture of
2,3-dygalloyl-4,6-HHDP-D-glucose (3a/3b) were isolated for the first time from Geranium molle L., a medicinal
plant used in the folk medicine of northeast of Portugal for the treatment of a variety of ailments, including
cancer. The cytotoxic activity of the isolated compounds was assessed against several human tumour cell lines
and non-tumour porcine liver primary cells. The anomeric mixture of ellagitannins 3a/3b, with the two anomers
showing considerably different hydrophobicities, was found to be significantly cytotoxic against cancer cells,
with only moderate hepatotoxicity.
Descrição
Palavras-chave
Cytotoxic activity Geranium molle L. Phenolic compounds Secondary metabolites
Contexto Educativo
Citação
Graça, V. C.; Calhelha, Ricardo C.; Nunes, Fernando M.; Berthet, Jérôme; Ferreira, Isabel C.F.R.; Santos, P. F. (2019). Isolation of secondary metabolites from Geranium molle L. with anticancer potential. Industrial Crops and Products. ISSN 0926-6690. 142, p. 1-5