Publication
The influence of ACE ID and ACTN3 R577X polymorphisms on lower-extremity function in older women in response to high-speed power training
| dc.contributor.author | Pereira, A. | |
| dc.contributor.author | Costa, Aldo M. | |
| dc.contributor.author | Leitão, José C. | |
| dc.contributor.author | Monteiro, A.M. | |
| dc.contributor.author | Izquierdo, Mikel | |
| dc.contributor.author | Silva, A.J. | |
| dc.contributor.author | Bastos, Estela | |
| dc.contributor.author | Marques, Mário C. | |
| dc.date.accessioned | 2015-11-17T12:27:41Z | |
| dc.date.available | 2015-11-17T12:27:41Z | |
| dc.date.issued | 2013 | |
| dc.description.abstract | Background:We studied the influence of the ACE I/D and ACTN3 R577X polymorphisms (single or combined) onlower-extremity function in older women in response to high-speed power training.Methods:One hundred and thirty-nine healthy older Caucasian women participated in this study (age: 65.5 ± 8.2 years,body mass: 67.0 ± 10.0 kg and height: 1.57 ± 0.06 m). Walking speed (S10) performance and functional capacityassessed by the“get-up and go”(GUG) mobility test were measured at baseline (T1) and after a consecutive 12-weekperiod of high-speed power training (40-75% of one repetition maximum in arm and leg extensor exercises; 3 sets4–12 reps, and two power exercises for upper and lower extremity). Genomic DNA was extracted from blood samples,and genotyping analyses were performed by PCR methods. Genotype distributions between groups were comparedby Chi-Square test and the gains in physical performance were analyzed by two-way, repeated-measures ANOVA.Results:There were no significant differences between genotype groups in men or women for adjusted baselinephenotypes (P > 0.05). ACE I/D and ACTN3 polymorphisms showed a significant interaction genotype-training only inS10 (P = 0.012 and P = 0.044, respectively) and not in the GUG test (P = 0.311 and P = 0.477, respectively). Analyses ofthe combined effects between genotypes showed no other significant differences in all phenotypes (P < 0.05) atbaseline. However, in response to high-speed power training, a significant interaction on walking speed (P = 0.048)was observed between the“power”(ACTN3 RR + RX & ACE DD) versus“non-power”muscularity-oriented genotypes(ACTN3 XX & ACE II + ID)].Conclusions:Thus, ACE I/D and ACTN3 R577X polymorphisms are likely candidates in the modulation ofexercise-related gait speed phenotype in older women but not a significant influence in mobility traits. The influence of ACE ID and ACTN3 R577X polymorphisms on lower-extremity function in older women in response to high-speed power training. Available from: https://www.researchgate.net/publication/259244416_The_influence_of_ACE_ID_and_ACTN3_R577X_polymorphisms_on_lower-extremity_function_in_older_women_in_response_to_high-speed_power_training [accessed Nov 17, 2015]. | pt_PT |
| dc.identifier.citation | Pereira, Ana; Costa, Ana; Leitão José C.; Monteiro, A.M.; Izquierdo, Mikel; Silva, A.J.; Bastos, Estela; Marques, Mário C. (2013). The influence of ACE ID and ACTN3 R577X polymorphisms on lower-extremity function in older women in response to high-speed power training. BMC Geriatrics. ISSN 1471-2318. 13:1 | pt_PT |
| dc.identifier.doi | 10.1186/1471-2318-13-131 | pt_PT |
| dc.identifier.issn | 1471-2318 | |
| dc.identifier.uri | http://hdl.handle.net/10198/12352 | |
| dc.language.iso | eng | pt_PT |
| dc.peerreviewed | yes | pt_PT |
| dc.publisher | Biomed Central Ltd. | pt_PT |
| dc.relation | SFRH/BD/47114/2008, funded by POPH–QREN, shared by theEuropean Social Fund and the national funds of MCTES. This work wassupported in part by the Spanish Department of Health and Institute CarlosIII of the Government of Spain [Spanish Net on Aging and frailty; (RETICEF)]and Economy and Competitivity Department of the Government of Spain,under grants numbered RD12/043/0002, and DEP2011-24105, respectively The influence of ACE ID and ACTN3 R577X polymorphisms on lower-extremity function in older women in response to high-speed power training. Available from: https://www.researchgate.net/publication/259244416_The_influence_of_ACE_ID_and_ACTN3_R577X_polymorphisms_on_lower-extremity_function_in_older_women_in_response_to_high-speed_power_training [accessed Nov 17, 2015]. | pt_PT |
| dc.relation.ispartofseries | 1;131 | |
| dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | pt_PT |
| dc.subject | Resistance training | pt_PT |
| dc.subject | Angiotensin converting-enzyme | pt_PT |
| dc.subject | Alpha-Actinin-3 | pt_PT |
| dc.subject | Women | pt_PT |
| dc.subject | Lower mobility | pt_PT |
| dc.title | The influence of ACE ID and ACTN3 R577X polymorphisms on lower-extremity function in older women in response to high-speed power training | pt_PT |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.citation.title | BMC Geriatrics | pt_PT |
| oaire.citation.volume | 13 | pt_PT |
| person.familyName | Monteiro | |
| person.givenName | António M. | |
| person.identifier.ciencia-id | C41C-6CCD-A1F0 | |
| person.identifier.orcid | 0000-0003-4467-1722 | |
| rcaap.rights | openAccess | pt_PT |
| rcaap.type | article | pt_PT |
| relation.isAuthorOfPublication | 5b5d8601-e683-42d5-a1b5-c8e29a4e0a41 | |
| relation.isAuthorOfPublication.latestForDiscovery | 5b5d8601-e683-42d5-a1b5-c8e29a4e0a41 |