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Phenolic composition and hepatotoxicity assessment of Cytisus striatus (Hill) Rothm. infusion

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dc.contributor.authorBarros, Lillian
dc.contributor.authorPereira, Carla
dc.contributor.authorCalhelha, Ricardo C.
dc.contributor.authorDueñas, Montserrat
dc.contributor.authorCarvalho, Ana Maria
dc.contributor.authorSantos-Buelga, Celestino
dc.contributor.authorFerreira, Isabel C.F.R.
dc.date.accessioned2014-03-27T16:11:43Z
dc.date.available2014-03-27T16:11:43Z
dc.date.issued2013
dc.description.abstractCytisus striatus (Hill) Rothm.is a species from the Tribe Genisteae (Fam. Fabaceae, subFam. Faboideae) commonly encountered in the Portuguese wild flora. In several regions of Portugal, this Fabaceae is used for medicinal purposes as it is considered to have anti-inflammatory properties (Carvalho, 2010). Some antioxidants were found in this plant, including tocopherols (Pinela et al., 2011) and ascorbic acid (Pereira et al., 2013), that could be related to the mentioned properties. Nevertheless, their composition in other important antioxidants such as phenolic compounds remains unknown. It should be pointed out that folk medicine recommends specific dosages and controls the periods of intake to avoid some risks empirically associated to oral dosage forms of this plant. Therefore, the aim of the present work was to determine the phenolic composition of Cytisus striatus infusion and to evaluate its hepatotoxicity. The analysis of phenolic compounds was carried out by reversed-phase HPLC-DAD and the major phenolic compounds were identified by ESI-MS. The hepatotoxicity was assessed by sulphorhodamine B assay using a porcine liver primary culture (PLP-2) established by us. The main phenolic compounds found in the infusion were p-coumaroyl acid, luteolin and apigenin derivatives and chrysin, being this last one the most abundant compound. The sample did not reveal toxicity for non-tumour cells. These results give scientific and technical support to the traditional use of this plant in folk medicine, highlighting this species as a source of bioactive compounds, such as phenolic compounds, that could be incorporated in functional beverages or other formulations.por
dc.description.sponsorshipFundação para a Ciência e a Tecnologia (FCT, Portugal) for financial support to CIMO (strategic project PEst-OE/AGR/UI0690/2011). R.C. Calhelha and L. Barros also thank to FCT, POPHQREN and FSE for their grants (SFRH/BPD/BPD/68344/2010 and SFRH/BPD/4609/2008, respectively). The GIP-USAL is financially supported by the Spanish Consolider-Ingenio 2010 Programme (Fun-c-Food, ref. CSD2007-00063). M. Dueñas also thanks the Spanish ‘‘Ramón y Cajal’’ Programme for a contract.por
dc.identifier.citationBarros, Lillian; Pereira, Carla; Calhelha, Ricardo C.; Dueñas, Montserrat; Carvalho, Ana Maria; Santos-Buelga, Celestino; Ferreira, Isabel C.F.R. (2013). Phenolic composition and hepatotoxicity assessment of Cytisus striatus (Hill) Rothm. infusion. In 1st International Symposium on Profiling. Almada. ISBN 978-989-98415-5-0por
dc.identifier.isbn978-989-98415-5-0
dc.identifier.urihttp://hdl.handle.net/10198/9393
dc.language.isoengpor
dc.peerreviewedyespor
dc.relationSFRH/BPD/4609/2008
dc.relationStrategic Project - UI 690 - 2011-2012
dc.titlePhenolic composition and hepatotoxicity assessment of Cytisus striatus (Hill) Rothm. infusionpor
dc.typeconference object
dspace.entity.typePublication
oaire.awardTitleStrategic Project - UI 690 - 2011-2012
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/PEst-OE%2FAGR%2FUI0690%2F2011/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBPD%2F68344%2F2010/PT
oaire.citation.conferencePlaceCaparica – Portugalpor
oaire.citation.title1st International Symposium on Profilingpor
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStreamSFRH
person.familyNameBarros
person.familyNamePereira
person.familyNameCalhelha
person.familyNameCarvalho
person.familyNameFerreira
person.givenNameLillian
person.givenNameCarla
person.givenNameRicardo C.
person.givenNameAna Maria
person.givenNameIsabel C.F.R.
person.identifier469085
person.identifier1415151
person.identifierID G-7399-2011
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person.identifier.orcid0000-0002-9050-5189
person.identifier.orcid0000-0003-0093-771X
person.identifier.orcid0000-0002-6801-4578
person.identifier.orcid0000-0001-5508-5935
person.identifier.orcid0000-0003-4910-4882
person.identifier.ridJ-3600-2013
person.identifier.ridK-1629-2016
person.identifier.ridJ-2172-2014
person.identifier.ridE-8500-2013
person.identifier.scopus-author-id35236343600
person.identifier.scopus-author-id55627876424
person.identifier.scopus-author-id6507978333
person.identifier.scopus-author-id20336503900
person.identifier.scopus-author-id36868826600
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
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