Logo do repositório
 
Publicação

Maternal longevity is associated with reduced risk but an earlier onset of alzheimer’s disease in offspring

2026Artigo científico Acesso aberto
Ver registo simples
datacite.subject.fosCiências Médicas::Ciências da Saúde
datacite.subject.sdg03:Saúde de Qualidade
datacite.subject.sdg04:Educação de Qualidade
dc.contributor.authorTábuas-Pereira, Miguel
dc.contributor.authorMano, Francisco
dc.contributor.authorBernardes, Catarina
dc.contributor.authorDurães, João
dc.contributor.authorLima, Marisa
dc.contributor.authorDenHaan, Kaitlyn
dc.contributor.authorPaquette, Kimberly
dc.contributor.authorKun-Rodrigues, Célia
dc.contributor.authorCarmona, Susana
dc.contributor.authorTábuas, Teresa
dc.contributor.authorFaustino, Pedro
dc.contributor.authorCoelho, Mariana Ruth
dc.contributor.authorSilva-Spínola, Anuschka
dc.contributor.authorDuro, Diana
dc.contributor.authorAlmeida, Maria Rosário
dc.contributor.authorMalva, João
dc.contributor.authorBaldeiras, Inês
dc.contributor.authorBrás, José
dc.contributor.authorGuerreiro, Rita
dc.contributor.authorSantana, Isabel
dc.date.accessioned2026-03-10T14:55:12Z
dc.date.available2026-03-10T14:55:12Z
dc.date.issued2026
dc.description.abstractWhile human longevity has increased significantly over the last 2 centuries, the time spent in good physical and cognitive health has not risen proportionately. The incidence of Alzheimer’s disease (AD) increases with age, but parental longevity is often associated with better offspring health and lower AD risk. This study aimed to investigate the relationship between parental longevity and AD. We included patients with AD and cognitively healthy subjects (over 75 years), collecting family history data, namely maternal and paternal age at death. We performed a logistic regression to evaluate the association of parental longevity and AD risk and linear regression models for the association with age of onset and CSF biomarkers, adjusting for confounders. We analyzed 3069 participants from a Portuguese cohort, including 893 AD patients and 2176 cognitively healthy controls. Maternal longevity was inversely associated with AD risk (OR: 0.989, 95%CI = [0.982, 0.997], P = 0.005). In AD patients, higher maternal age of death was associated with an earlier disease onset (β = −0.081, 95%CI = [−0.148, −0.013], P = 0.019). No associations were found between parental longevity and CSF biomarkers. Maternal longevity appears protective against AD risk but is linked to an earlier onset in patients. This may indicate that protective factors for AD could become detrimental once AD is triggered. These findings highlight the complex interplay of genetic, environmental, and potentially epigenetic influences on AD.eng
dc.description.sponsorshipThe authors disclosed receipt of the following financial support for theresearch, authorship, and/or publication of this article: Research re-ported in this publication was supported by the National Institute onAging of the National Institutes of Health under Award NumberR01AG067426. The content is solely the responsibility of the authorsand does not necessarily represent the official views of the NationalInstitutes of Health. The study was also supported by EU HorizonEurope CHAngeing - Excellence Hubs-HORIZON WIDERA-2022-ACCESS-04-01 (grant agreement #101087071).
dc.identifier.citationTábuas-Pereira, Miguel; Mano, Francisco; Bernardes, Catarina; Durães, João; Lima, Marisa; DenHaan, Kaitlyn; Paquette, Kimberly; Kun-Rodrigues, Célia; Carmona, Susana; Tábuas, Teresa; Faustino, Pedro; Coelho, Mariana R.; Silva-Spínola, Anuschka; Duro, Diana; Almeida, Maria R.; Malva, João; Baldeiras, Inês; Brás, José; Guerreiro, Rita; Santana, Isabel (2026). Maternal Longevity is Associated WithReduced Risk but an Earlier Onset ofAlzheimer’s Disease in Offspring. Journal of Geriatric Psychiatryand Neurology. ISSN 1552-5708. 0:0, p, 1-7.
dc.identifier.doi10.1177/08919887261424534
dc.identifier.issn0891-9887
dc.identifier.issn1552-5708
dc.identifier.urihttp://hdl.handle.net/10198/35999
dc.language.isoeng
dc.peerreviewedyes
dc.publisherSAGE Publications
dc.relation.ispartofJournal of Geriatric Psychiatry and Neurology
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/
dc.subjectAge
dc.subjectAlzheimer
dc.subjectAmyloid
dc.subjectEndophenotypes
dc.subjectLongevity
dc.subjectMaternal
dc.subjectPaternal
dc.titleMaternal longevity is associated with reduced risk but an earlier onset of alzheimer’s disease in offspringeng
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage7
oaire.citation.issue0
oaire.citation.startPage1
oaire.citation.titleJournal of Geriatric Psychiatryand Neurology
oaire.citation.volume0
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85

Ficheiros

Principais
A mostrar 1 - 1 de 1
Miniatura
Nome:
Maternal Longevity is Associated.pdf
Tamanho:
510.75 KB
Formato:
Adobe Portable Document Format
Ver/Abrir
Licença
A mostrar 1 - 1 de 1
Miniatura indisponível
Nome:
license.txt
Tamanho:
1.75 KB
Formato:
Item-specific license agreed upon to submission
Descrição:
Ver/Abrir

Coleções

ESSa - Artigos em Revistas Indexados à WoS/Scopus