Ferreira, Isabel C.F.R.Calhelha, Ricardo C.Estevinho, Leticia M.Queiroz, Maria João R.P.2008-09-122008-09-122004Ferreira, Isabel C.F.R.; Calhelha, Ricardo C.; Estevinho, Leticia M.; Queiroz, Maria João R.P. (2004). Screening of antimicrobial activity of diarylamines in the 2,3,5-trimethylbenzo[b]thiophene series: A structure-activity evaluation study. Bioorganic & Medicinal Chemistry Letters. ISSN 0960-894X. 14:23, p. 5831-58330960-894Xhttp://hdl.handle.net/10198/821Gram positive (Bacillus cereus, B. subtilis), Gram negative (Pseudomonas aeruginosa, Escherichia coli) bacteria, and Candida albicans as a representative of fungi were used for screening the in vitro antimicrobial activity of diarylamines in the 2,3,5-trimethylbenzo[ b]thiophene series bearing different substituents, synthesized by us using the palladium-catalyzed C–N coupling methodology. The minimal inhibitory concentration (MIC) and structure–activity relationships (SARs) were evaluated.engDiarylaminesAntimicrobial activitySARBenzothiophenesjournal article10.1016/j.bmcl.2004.09.038