Froufe, Hugo J.C.Abreu, Rui M.V.Ferreira, Isabel C.F.R.2011-11-042011-11-042011Froufe, Hugo J.C.; Abreu, Rui M.V.; Ferreira, Isabel C.F.R. (2011). QCAR models to predict wild mushrooms radical scavenging activity, reducing power and lipid peroxidation inhibition. Chemometrics and Intelligent Laboratory Systems. ISSN 0169-7439. 109:2, p. 192-1960169-7439http://hdl.handle.net/10198/6271Wild mushrooms have become attractive as a source of physiologically beneficial compounds including antioxidants such as phenolic compounds and tocopherols. The concentrations of antioxidant compounds (phenolics and α-tocopherol) and EC50 values of antioxidant activity (concentration required to achieve 50% of radical scavenging activity and lipid peroxidation inhibition, or 0.5 of absorbance in reducing power) were analyzed by partial least square (PLS) regression analysis. Three QCAR (Quantitative Composition-Activity Relationship) models were constructed and their robustness and predictability were verified by internal and external cross-validation methods. Antioxidant activity correlated well with phenolics and -tocopherol contents, the major antioxidants in wild mushrooms. The models proved to be useful tools in the prediction of mushrooms radical scavenging activity, reducing power and lipid peroxidation inhibition.engWild mushroomsPhenolicsAlpha-tocopherolAntioxidant activityQCARPLSjournal article10.1016/j.chemolab.2011.09.004