Ribeiro, António E.Pais, Luís S.Rodrigues, Alírio2014-01-132014-01-132012Ribeiro, António E.; Pais, L. S.; Rodrigues, Alírio E. (2012). Chiral separation of nadolol stereoisomers by liquid chromatography : screening of mobile phase composition and SMB separation. In ANQUE's International Congress of Chemical Engineering (ANQUE-ICCE 2012. Sevilla, Spainhttp://hdl.handle.net/10198/9145This work describes a systematic approach to rapid development of simulated moving bed (SMB) chiral chromatographic separations. The presented methodology involves several pulse experiments using a single-column to screen the best mobile phase composition using a Chiralpak AD stationary phase and equilibrium adsorption data used to specify the initial flow rates of the SMB operation.engNadololChiral separationMobile phase compositionSimulated moving redconference object