Campos, Joana F.Begouin, AgathePeixoto, DanielaFroufe, Hugo J.C.Abreu, Rui M.V.Ferreira, Isabel C.F.R.Queiroz, Maria João R.P.2013-09-092013-09-092013Campos, Joana F.; Begouin, Agathe; Peixoto, Daniela; Froufe, Hugo J.C.; Abeu, Rui M.V.; Ferreira, Isabel C.F.R.; Queiroz, Maria-João R. P. (2013). Synthesis of new N-[3-(thieno[3,2-b]pyridine-7-ylthio)phenyl]benzamides as potential inhibitors the tyrosine kinase domain of VEGFR2. In 1st Symposium on Medicinal Chemistry. Bragahttp://hdl.handle.net/10198/8688Angiogenesis, the growth of new vessels from preexisting vasculature, is a critical step in tumor progression [1]. The tyrosine kinase Vascular Endothelial Growth Factor Receptor 2 (VEGFR2) is a crucial mediator in angiogenesis since the VEGF, excreted by the tumor cells, binds to it activating several signaling pathways involved in cell survival and proliferation [2]. Recently thienopyridine derivatives showed to be promising inhibitors of the tyrosine kinase domain of VEGFR2 [3,4]. In this work new N-[3-(thieno[3,2-b]pyridine-7-ylthio)phenyl]benzamides were prepared as potential VEGFR2 inhibitors suggested by rational design, as presented below.engconference object