Arafah, RamiRibeiro, António E.Rodrigues, AlírioPais, Luís S.2020-06-152020-06-152018Arafah, Rami; Ribeiro, António E.; Rodrigues, A.E.; Pais, L.S. (2018). Separation of nadolol racemates by high pH reversed-phase simulated moving bed chromatography. In 13th International Chemical and Biological Engineering Conference. Aveiro. ISBN 978-972-789-566-3978-972-789-566-3http://hdl.handle.net/10198/22055Nadolol is a pharmaceutical drug marketed as a mixture of four stereoisomers, used to treat cardiovascular diseases. This drug is a mixture of two pairs of racemates, therefore, its complete separation represents a challenging task. Recently, our research group reported the pseudo-binary separation of nadolol by SMB chromatography using both coated Chiralpak AD and Chiralpak IA immobilized chiral stationary phases. In this work, we present an alternative strategy, implementing a first achiral separation step, by using C18 columns to perform the separation of the two pairs of nadolol racemates under reversed-phase mode. Extensive experimental and simulation results will be presented including solvent screening, measurement of equilibrium and kinetic data, and both fixed-bed and SMB preparative separations. Extensive experimental and simulation results will be presented, including solvent screening, measurement of equilibrium adsorption isotherms, breakthrough measurements, and SMB (FlexSMB-LSRE unit) experimental preparative separation using C18 columns.engNadolol racematesconference object