Pinto, ElmanoTaboada, Bruna Rafaela PereiraFaustino, VeraCidre, DianaRodrigues, Raquel OliveiraMiranda, João MárioGarcia, ValdemarDias, Ricardo P.Lima, Rui A.2013-09-122013-09-122013Pinto, E.; Taboada, B.; Faustino, V.; Cidre, D.; Rodrigues, R.; Miranda, J.; Garcia, V.; Dias, Ricardo; Lima, R. (2013). Blood flow in microchannels manufactured by a low cost technique: xurography. In Eds. Rubio-Hernández F. J. [et al.] Perspectives in Fundamental and Applied Rheology. Gráficas Fernando. p. 285-290. ISBN 978-84-616-5245-7978-84-616-5245-7http://hdl.handle.net/10198/8738The xurography is a technique that has been used to make molds to produce microchannels. In contrast to soft lithography [1, 2], xurography uses equipments and materials commonly used in the printing industry, such as cutting plotters, vinyl and other materials. The main advantage of this technique is to fabricate microchannels at a reduced cost [3, 4]. The Fahraeus-Lindqvist effect is a well know phenomenon that happens in microcirculation, where red blood cells (RBCs) have tendency to migrate toward the centre of the microtube resulting in a marginal cell-free layer (CFL) at regions adjacent to the wall [5]. Recently several studies showed strong evidence that the formation of the CFL is affected by the geometry of the microchannel [1, 6, 7] and the physiological conditions of the working fluid, such as the hematocrit (Hct) [2, 8]. The main objective of the present work is to fabricate polydimethysiloxane (PDMS) microchannels by using a soft xurography technique in order perform blood flow studies. Additionally, a high-speed video microscopy system is used to measure the CFL thickness in two different geometries, i. e., bifurcations and confluences.engBlood flowXurograpgyCell free layerBifurcationsbook part