Tomé, Sara M.Silva, ArturSantos, Clementina M.M.2015-03-022015-03-022014Tomé, Sara M.; Silva, Artur M.S.; Santos, Clementina M.M. (2014). Synthesis and transformation of halochromones. Current Organic Synthesis. ISSN 1570-1794. 11:3, p. 317-3411570-1794http://hdl.handle.net/10198/11714Chromones (4H-1-benzopyran-4-ones) are one of the most abundant groups of naturally occurring oxygen containing heterocyclic compounds possessing a benzo-γ-pyrone framework, 1a. The significance of these widely spread and highly diverse compounds is far beyond the important biological functions they assume in nature [1, 2]. Natural and synthetic chromone derivatives have been assigned as lead structures in drug development with some already being marketed [3]. The majority of the naturally occurring chromones are 2- and 3-aryl derivatives, called flavones 1b and isoflavones 1c, respectively. However, other types of chromones have also been found in the plant kingdom, such as 3-methylchromones 1d and 2- styrylchromones 1e (Fig. 1).engChromonesCross-coupling reactionsHalochromonesHalogenationReactivitySynthesisjournal article10.2174/15701794113109990063