Del Angelo, Gabriela LuccaOliveira, Isabela Silva deAlbuquerque, Bianca R.Kagueyama, Samanta ShiraishiSilva, Tamires Barlati VieiraSantos Filho, José Rivaldo dosDias, Maria InêsPereira, CarlaCalhelha, Ricardo C.Alves, Maria JoséFerrari, ArianaYamaguchi, Natalia UedaZielinski, Acacio A.F.Bracht, AdelarPeralta, Rosane M.Corrêa, Rúbia C.G.2024-12-202024-12-202024Del Angelo, Gabriela Lucca; Oliveira, Isabela Silva de; Albuquerque, Bianca Rodrigues de; Kagueyama, Samanta Shiraishi; Silva, Tamires Barlati Vieira da; Santos Filho, José Rivaldo dos; Dias, Maria Inês; Pereira, Carla; Calhelha, Ricardo C.; Alves, Maria José; Ferrari, Ariana; Yamaguchi, Natalia Ueda; Zielinski, Acácio Antonio Ferreira; Bracht, Adelar; Peralta, Rosane Marina; Corrêa, Rúbia Carvalho Gomes (2024). Jatoba (Hymenaea courbaril L.) Pod Residue: A Source of Phenolic Compounds as Valuable Biomolecules. Plants. ISSN 2223-7747. 13:22, p. 1-122223-7747http://hdl.handle.net/10198/30775This study aimed at investigating the chemical composition and a selected group of bioactivities of jatoba (Hymenaea courbaril L.) pod residue. An aqueous extract (deionized water; AE) and a hydroethanolic extract (ethanol: deionized water, 70:30 v/v; ETOH) were obtained via maceration. Ten phenolic compounds were characterized via LC-DAD-ESI/MSn: seven procyanidins, two quercetin derivatives and one taxifolin derivative, with dimers and trimers of procyanidins being the main components of both extracts. Total phenolic compound levels of 2.42 ± 0.06 and 11 ± 1 mg/g were found in AE and ETOH, respectively; however, only seven compounds were identified in ETOH. The jatoba pod residue extracts showed notable antioxidant activities: ETOH had greater antioxidant potential in the OxHLIA and DPPH assays (IC50 = 25.4 μg/mL and 0.71 μg/mL, respectively); however, EA demonstrated greater potential in the FRAP system (IC50 = 2001.0 μM TE/mg). Only AE showed antiproliferative potential, being effective against cell lines of gastric (GI50 = 35 ± 1 μg/mL) and breast (GI50 = 89 ± 4 μg/mL) adenocarcinomas. Likewise, only AE showed modest anti-inflammatory potential (IC50 = 225 ± 2 μg/mL) in mouse macrophages. Bacteriostatic effects against bacteria were exerted by both extracts. Enterococcus faecalis and Listeria monocytogenes (MICs = 2.5 mg/mL) were especially sensitive to the ETOH extract. Taken together, the results suggest potential for jatoba pod residue as a source of molecules with biological activities and with possible industrial applications.engFood waste recoveryPhenolic compoundsAntioxidant potentialAntiproliferative potentialAntimicrobial activityUpcyclingjournal article10.3390/plants13223207