Alonso-Sardón, MontserratPaulino, ManuelFernandes, AdíliaMartín-Delgado, María AntoniaPérez-Martín, Raixa NoemíMagalhães, Carlos PiresPimentel, Maria HelenaMata, Maria AugustaSilvano, JustinaCorte, Agostinha2026-03-062026-03-062023Alonso-Sardón, Montserrat; Paulino, Manuel; Fernandes, Adília; Martín-Delgado, María Antonia; Pérez-Martín, Raixa Noemí; Magalhães, Carlos Pires; Pimentel, Maria Helena; Mata, Maria Augusta; Silvano, Justina; Corte, Agostinha (2023). Epidemiological impact of neurodegenerative diseases in the rural Spanish-Portuguese cross-border region. Neurodegenerative Diseases . ISSN 1660-2854. 23:3-4, p. 25-341660-2854http://hdl.handle.net/10198/35982Epidemiological data indicate that neurodegenerative diseases show a high prevalence with a progressive increasing trend, especially in aging populations, as is the case in rural areas. The objective of this study was to assess the quantitative impact of neurodegenerative diseases in rural areas of the Spanish-Portuguese border region and to describe the epidemiological profile of the most prevalent disorders in one of the most depopulated and aged regions of Europe. Methods: A cross-sectional descriptive study was designed to estimate the prevalence of subjects diagnosed with the most common neurodegenerative disorders: dementia (Alzheimer’s disease and other dementias), Parkinson’s disease and Parkinsonism, and multiple sclerosis in the Spanish-Portuguese cross-border border region in 2020. It includes Bragança and Guarda Districts (Portugal) and Salamanca (Castilla y León, Spain). Results: Neurodegenerative diseases accounted for 1.85% in the Spanish-Portuguese cross-border region in 2020; a total of 5,819 records were reported: 987 (prevalence, 2.51%) in Salamanca (Spain); 2,332 (prevalence, 1.87%) in Bragança; and 2,500 (prevalence, 1.66%) in Guarda. Female population suffered from them in higher proportion (2.35 vs. 1.32%). Dementia represented 1.19% (3,744), Parkinson’s disease and Parkinsonism 0.58% (1,823), and multiple sclerosis 0.08% (252). These disorders impacted older age groups. In the ruralengAlzheimer’s diseaseMultiplesclerosisNeurodegenerative diseasesParkinson’sdiseasejournal article10.1159/000535683