Shiraishi, Carlos S.H.Souza, Sérgio F.Prieto Lage, Miguel A.Barros, LillianAbreu, Rui M.V.2023-01-052023-01-052022Shiraishi, Yoshiki; Souza, Sérgio F.; Prieto Lage, Miguel A.; Barros, Lillian; Abreu, Rui M.V. (2022). Virtual screening of a library of natural compounds against COX-2 protein. In Biovia Conference 2022. Bioviahttp://hdl.handle.net/10198/26339The use of nonsteroidal anti-inflammatory drugs (NSAIDs) in treating inflammatory diseases has been widespread, especially in treating rheumatoid arthritis. NSAIDs act mainly by promoting the inhibition of cyclooxygenase enzymes (COX-1 and COX-2), inducing significant anti-inflammatory, analgesic, and antipyretic activity. However, recent data show that prolonged use of NSAIDs can lead to cardiovascular side effects. Thus, the present work aims to identify COX-2 inhibitors alternatives from natural sources, specifically mushrooms, as an alternative to conventional inhibitors.engCOX-2 proteinResearch Subject Categories::FORESTRY, AGRICULTURAL SCIENCES and LANDSCAPE PLANNING::Product science::Food scienceconference poster