Valles, ElenaGarcía, Pablo A.Miguel del Corral, José MaríaPérez, MartaFerreira, Isabel C.F.R.Calhelha, Ricardo C.San Feliciano, ArturoCastro, María Ángeles2016-12-222016-12-222016Valles, Elena; García, Pablo A.; Miguel del Corral, José María; Pérez, Marta; Ferreira, Isabel C.F.R.; Calhelha, Ricardo C.; San Feliciano, Arturo; Castro, María Ángeles (2016). Synthesis and cytotoxic evaluation of new terpenylpurines. RSC Advances. ISSN 2046-2069. 107:6, p. 105412-105420http://hdl.handle.net/10198/13641Several new terpenylpurine derivatives were prepared through alkylation of different purines with halogenated reagents derived from natural terpenoids, commercially available or isolated from cones of C. sempervirens L. and further transformed into appropriate alkylated agents. Alkylation of the purines gave mixtures of 9- and 7-alkylpurines, being the 9-alkylpurines the major regioisomers. The presence of the terpenyl residue induced cytotoxicity on simple purines and, in general, that activity improved as the substituent was larger. The 7-diterpenyl-6-chloropurine E-21b was the most cytotoxic in the series and it can be considered an analogue of the marine natural compounds agelasines and agelasimines, which were taken as models for this work.engjournal article10.1039/C6RA24254E