Tetrahydroquinazoline-substituted chromones from Diels–Alder reaction of (E)-2-styrylchromones and pyrimidine ortho-quinodimethane

Patoilo, DianaSilva, ArturPinto, DianaSantos, Clementina M.M.Tomé, AugustoCavaleiro, José2013-03-152013-03-1520120040-4039http://hdl.handle.net/10198/8274The Diels-Alder reaction of (E)-2-styrylchromones with a pyrimidine ortho-quinodimethane is reported for the first time. These cycloaddition reactions afford mixtures of two regioisomeric tetrahydroquinazoline-substituted chromones in moderate to excellent global yields. Irrespectively of the substituents on the 2-styrylchromones, the 2-(7-aryl-4-methoxy-2-methyl-5,6,7,8-tetrahydroquinazolin-6-yl)chromone derivatives are always the major isomers.engTetrahydroquinazolinesCycloadditions2-StyrylchromonesPyrimidine ortho-QuinodimethaneNMRTetrahydroquinazoline-substituted chromones from Diels–Alder reaction of (E)-2-styrylchromones and pyrimidine ortho-quinodimethanejournal article10.1016/j.tetlet.2012.03.081