Silva, Vera L.M.Pinto, DianaSantos, Clementina M.M.Rocha, Djenisa2022-10-102022-10-102022Silva, Vera L.M.; Pinto, Diana; Santos, Clementina M.M.; Rocha, Djenisa (2022). Quinolinones and related systems (Update 2022). In Science of Synthesis Knowledge Updates 2022/3. Stuttgart: Georg Thieme Verlag KG, p. 183-442978-3-13-245285-5http://hdl.handle.net/10198/25967Quinolinones, of which the quinolin-4(1H)-one ring system can be highlighted, represent an exciting class of nitrogen heterocycles. The quinolinone motif can be found in many natural compounds and approved drugs for several diseases. This chapter is a comprehensive survey of the methods for the synthesis of quinolin-2(1H)-ones, quinolin-4(1H)-ones, and their thio- and amino derivatives, and is an update to the previous Science of Synthesis chapter (Section 15.4), covering the period between 2003 and 2020.engAmidesAminesAnilidesAnnulationsCarbon–carbon bondsCarbon– nitrogen bondsCarbonyl compoundsEnaminonesHeterocyclesLactamizationQuinolinesQuinolinaminesRing-closing reactionsRing expansionTandem reactionsPalladium catalystsbook part10.1055/sos-SD-115-01218