Graça, Vânia C.Calhelha, Ricardo C.Nunes, Fernando M.Berthet, JérômeFerreira, Isabel C.F.R.Santos, Paulo F.2018-02-192020-01-032018-01-192020-01-032019Graça, V. C.; Calhelha, Ricardo C.; Nunes, Fernando M.; Berthet, Jérôme; Ferreira, Isabel C.F.R.; Santos, P. F. (2019). Isolation of secondary metabolites from Geranium molle L. with anticancer potential. Industrial Crops and Products. ISSN 0926-6690. 142, p. 1-50926-6690http://hdl.handle.net/10198/10469Two flavone glycosides, apigenin-6-C-glucoside (1) and lutelin-6-C-glucoside (2), and an anomeric mixture of 2,3-dygalloyl-4,6-HHDP-D-glucose (3a/3b) were isolated for the first time from Geranium molle L., a medicinal plant used in the folk medicine of northeast of Portugal for the treatment of a variety of ailments, including cancer. The cytotoxic activity of the isolated compounds was assessed against several human tumour cell lines and non-tumour porcine liver primary cells. The anomeric mixture of ellagitannins 3a/3b, with the two anomers showing considerably different hydrophobicities, was found to be significantly cytotoxic against cancer cells, with only moderate hepatotoxicity.engCytotoxic activityGeranium molle L.Phenolic compoundsSecondary metabolitesjournal article10.1016/j.indcrop.2019.111859