Ferreira, Isabel C.F.R.Queiroz, Maria João R.P.Kirsch, Gilbert2008-09-122008-09-122003Ferreira, Isabel C.F.R.; Queiroz, Maria João R.P.; Kirsch, Gilbert (2003). Tandem palladium-catalyzed borylation and suzuki coupling (BSC) to thienocarbazole precursors. Tetrahedron Letters. ISSN 0040-4039. 44:23 (2003) p. 4327-43290040-4039http://hdl.handle.net/10198/819Substituted 2-methyl-2'-nitro diaryl compounds in the benzo[b]thiophene series were prepared by palladium-catalyzed, two-step, one-pot borylation/Suzuki coupling (BSC) reaction in good to high yields. The borylation reaction was performed on methylated 6-bromobenzo[b]thiophenes using pinacolborane and was followed by in situ Suzuki coupling with substituted (CF3, OMe) 2-bromonitrobenzenes. The compounds obtained were cyclized to the corresponding ring A substituted thienocarbazoles which can have biological activity or/and be used as biomarkers due to their fluorescence properties and possible DNA intercalation.engPalladiumBorylationSuzuki coupling2-methyl-2'-nitro biarylsBenzo[b]thiophenesjournal article10.1016/S0040-4039(03)00952-3