Aylanc, VolkanErtosun, SeymanurAkyuz, LalehanKoc Bilican, BehlulGokdag, SemihBilican, IsmailCakmak, Yavuz SelimYilmaz, Bahar AkyuzKaya, Murat2018-02-192020-06-222018-01-192020-06-222020Aylanc, Volkan; Ertosun, Seymanur; Akyuz, Lalehan; Koc Bilican, Behlul; Gokdag, Semih; Bilican, Ismail; Cakmak, Yavuz Selim; Yilmaz, Bahar Akyuz; Kaya, Murat (2020). Natural β-chitin-protein complex film obtained from waste razor shells for transdermal capsaicin carrier. International Journal of Biological Macromolecules. ISSN 0141-8130. 155, p. 508-5150141-8130http://hdl.handle.net/10198/20282In the literature, the produced β-chitin samples are in powder or flake forms but there is no natural β-chitin based film. Also, the commercially available transdermal patches are produced from synthetic polymers. In this regard,we produced natural β-chitin-protein complex (CPC) film fromthewaste shells of Ensis spp. The obtained natural filmwas characterized by FTIR, TGA and SEM. Additionally, swelling, thickness, contact angle and antioxidant tests were done to learn more about the films. After production and characterization of the film, capsaicin, which is commonly used for pain reliefwas loaded into the film. The loading capacitywas recorded as 5.79%. The kineticmodelswere studied in three different pH, then the resultswere fittedwith Higuchimodelwith high correlation at pH 7.4. After considering all the obtained results, the capsaicin loaded CPC film may be an alternative candidate for transdermal patch instead of the synthetic ones.engBio-wasteBiodegradable filmCapsaicinTransdermal patchβ-chitinjournal article10.1016/j.ijbiomac.2020.03.232