Filipe, Márcia SantosDominguez, EvaIsca, VeraPereira, RaquelMandim, FilipaCalhelha, Ricardo C.Diaz-Lanza, Ana MaríaBarros, LillianRijo, Patrícia2024-05-062024-05-062023Filipe, Márcia Santos; Dominguez, Eva; Isca, Vera; Pereira, Raquel; Mandim, Filipa; Calhelha, Ricardo C.; Diaz Lanza, Ana Maria; Barros, Lillian; Rijo, Patrícia (2023).Biological activity of 6,7-dehydroroyleanone derivatives from Plectranthus aliciae. Planta Médica. ISSN 0032-0943. 89:14, p. 13370032-0943http://hdl.handle.net/10198/29718Plectranthus genus (Lamiaceae) is known to be rich in bioactive abietane royleanone-type diterpenes, such as 6,7-dehydroxyroyleanone (1, Fig. 1), which have been previously found in P. madagascariensis (var. aliciae Codd). This abietane royleanone presents moderate to significant to cytoxic activity against several cancer cell lines. Moreover, 1 has one hydroxyl group suitable for deri- vatization that can be explored to enhance the cytotoxic activity of lead com- pound 1. Based on this, the aim of the present work is to explore the obtention of 1, from P. aliciae aliciae (Codd) van Jaarsv. & T.J.Edwards., a subspecies of P. madagascariensis to be further used in the preparation of new derivatives with enhanced biological activities.engconference object1439-0221