Finimundy, Tiane C.Barros, LillianCalhelha, Ricardo C.Alves, Maria JoséPrieto Lage, Miguel A.Abreu, Rui M.V.Dillon, Aldo J.P.Henriques, João A.P.Roesch-Ely, MarianaFerreira, Isabel C.F.R.2018-01-292018-01-292018-01-292018-01-292018Finimundy, Tiane C.; Barros, Lillian; Calhelha, Ricardo C.; Alves, Maria José; Prieto, Miguel A.; Abreu, Rui M.V.; Dillon, Aldo J.P.; Henriques, João A.P.; Roesch-Ely, Mariana; Ferreira, Isabel C.F.R. (2018). Multifunctions of Pleurotus sajor-caju (Fr.) Singer: A highly nutritious food and a source for bioactive compounds. Food Chemistry. ISSN 0308-8146. 245, p. 150-15803088146http://hdl.handle.net/10198/15073A study with Pleurotus sajor-caju was conducted to: evaluate the nutritional and chemical composition of the fruiting bodies; optimize the preparation of bioactive phenolic extracts; and characterize the optimized extract in terms of bioactive compounds and properties. P. sajor-caju revealed an equilibrated nutritional composition with the presence of hydrophilic (sugars and organic acids) and lipophilic (tocopherols and PUFA) compounds. p-Hydroxybenzoic, p-coumaric and cinnamic acids were identified in the extract obtained with ethanol (30 g/l ratio) at 55 °C for 85 min. This extract showed antioxidant properties (mainly reducing power and lipid peroxidation inhibition), antibacterial activity against MRSA and MSSA and cytotoxicity against NCI-H460, MCF-7 and HeLa. Furthermore, as the extract showed capacity to inhibit NO production in Raw 264.7 macrophages, molecular docking studies were performed to provide insights into the anti-inflammatory mechanism of action, through COX-2 inhibition by the phenolic acids identified.engjournal article10.1016/j.foodchem.2017.10.088