Paula, Vanessa B.Dias, L.G.Estevinho, Leticia M.2018-04-262018-04-262016Paula, Vanessa B.; Dias, L.G.; Estevinho, Leticia M. (2016). Propolis phenolic compounds extraction using response surface methodology. In 5th Portuguese Young Chemists Meeting and lst European Young Chemists Meeting. Guimarãeshttp://hdl.handle.net/10198/17296Propolis is a complex resinous substance prepared by bees (as, Apis mellifera) using compounds collected from plants, buds and exudates, which are then mixed with wax, pollen and enzymes ofbees' saliva [1, 2]. It is used to seal openings and cracks in the hive walls, to isolate animal calcasses inside the beehive, and in the protection against parasites. This product hás attained much interest due to its chemical composition and fünctional properties. Recent publications emphasize its biological and health enhancing properties as, for instance, immunomodulatory, antitumoral, antimicrobial, anti-inflammatory. antioxidant, antiviral and antifungal [3, 4].engconference object