Utilize este identificador para referenciar este registo: http://hdl.handle.net/10198/9614
Título: Stimuli-responsive hydrogels synthesis using free radical and RAFT polymerization
Autor: Gonçalves, Miguel
Pinto, Virgínia
Costa, Rita
Dias, Rolando
Hernándes-Ortiz, Júlio
Costa, Mário Rui
Palavras-chave: Crosslinking
Hydrogels
RAFT
Stimuli-responsive polymers
Data: 2013
Editora: WILEY-VCH
Citação: Gonçalves, Miguel; Pinto, Virgínia; Costa, Rita; Dias, Rolando; Hernándes-Ortiz, Julio; Costa, Mário Rui (2013) - Stimuli-responsive hydrogels synthesis using free radical and RAFT polymerization. In Polymer Reaction Engineering – 11th International Workshop e Macromolecular Symposia - Special Issue: Polymer Reaction Engineering. Hamburg. WILEY-VCH. p. 41-54.
Resumo: Temperature and pH stimuli-responsive hydrogel particles were synthesized using inverse-suspension polymerization in batch stirred reactor. Different water soluble co-monomers were present in the initial mixture (e.g. N-isopropylacrylamide and acrylic acid) as well as crosslinkers with different functionalities. Different operating conditions such as polymerization temperature, monomers dilution, neutralization and the initial ratios of co-monomers and monomers/crosslinker were also tried. Hydrogel particles were produced considering classical free-radical polymerization (FRP) and also RAFT polymerization. Commercially available RAFT agents 4-cyano-4-phenylcarbonothioylthio-pentanoic acid (CPA), 2-(dodecylthiocarbonothioylthio)-2-methylpropionic acid (DDMAT) and cyanomethyl dodecyl trithiocarbonate (CDT) were alternatively used. Sampling at different polymerization times allowed the study of the kinetics of polymerization through the analysis by SEC of the soluble phase. A tetra-detector array with simultaneous detection of refractive index, light scattering, intrinsic viscosity and ultra-violet signals was used in these studies. Usefulness of in-line FTIR-ATR monitoring to study the building process of such networks was also assessed. The performance of hydrogel beads was studied through drug delivery tests triggered by changes in the environmental temperature and pH. This research aims to contribute for the elucidation of the connection between the synthesis conditions, molecular architecture and properties/performance of such advanced materials.
Peer review: yes
URI: http://hdl.handle.net/10198/9614
DOI: 10.1002/masy.201300045
Versão do Editor: http://onlinelibrary.wiley.com/doi/10.1002/masy.201300045/abstract
Aparece nas colecções:DTQB - Artigos em Proceedings Não Indexados ao ISI/Scopus

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