Utilize este identificador para referenciar este registo: http://hdl.handle.net/10198/9430
Título: Development of ketoprofen delivery systems based on aqueous polyurethane dispersions
Autor: Leite, E.
Fernandes, I.P.
Ayres, E.
Barreiro, M.F.
Silva-Cunha, A.
Palavras-chave: Ketoprofen
Aqueous polyurethane dispersions
Controlled release
Data: 2013
Citação: Leite, E.; Fernandes, I.; Ayres, E.; Barreiro, M-F.; Silva-Cunha, A. (2013). Development of ketoprofen delivery systems based on aqueous polyurethane dispersions. In 1st Symposium on Medical Chemistry. Braga, Portugal
Resumo: Ketoprofen (2-(3-benzoylphenyl) propionic acid) is a non-steroidal anti-inflammatory drug (NSAID) used to treat a wide range of acute and chronic inflammatory diseases, e.g., rheumatoid arthritis, osteoarthritis and ankylosing spondylitis. Its prolonged oral administration is associated with several gastrointestinal reactions such as irritation and ulceration. In this context, ketoprofen is a good candidate for controlled release administration systems. This work aims to test the suitability of using aqueous polyurethane dispersions (PUDs) as the base vehicle for producing ketoprofen controlled release systems. Polyester (polycaprolactone, PCL) and polyether (polypropylene glycol, PPG) based PUDs have been synthesized by using a modified pre-polymer method. Two chain extenders have been assayed (ethylenediamina (EDA) and hydrazine monohydrate (HYD)).
Peer review: yes
URI: http://hdl.handle.net/10198/9430
Aparece nas colecções:CIMO - Resumos em Proceedings Não Indexados à WoS/Scopus

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