Utilize este identificador para referenciar este registo: http://hdl.handle.net/10198/9107
Título: Visualization of the cell-free layer (CFL) in a PDMS microchannel with a micro-stenosis
Autor: Pinho, Diana
Yaginuma, Tomoko
Faustino, V.
Pinto, Elmano
Rodrigues, Raquel Oliveira
Cidre, Diana
Pereira, Ana I.
Lima, R.
Palavras-chave: Cell free layer
Plasma layer
Data: 2013
Editora: Rubio-Hernández, F. J., et al.
Citação: Pinho, D.; Yaginuma, T.; Faustino, V.; Pinto, E.; Rodrigues, R. O.; Cidre, D.; Pereira, Ana I.; Lima, R. (2013) - Visualization of the cell-free layer (CFL) in a PDMS microchannel with a micro-stenosis. In Rubio-Hernández, F.J. [et al.](eds) Perspectives in Fundamental and Applied Rheology. p.363-367.ISBN 978-84-616-6551-8
Resumo: Red blood cells (RBCs) have a tendency to undergo axial migration due to the parabolic velocity profile which results in a high shear stress around wall that forces the RBC to move towards the center induced by the tank treading motion of the RBC membrane. As a result there is a formation of cell-free layer (CFL) with extremely low concentration of cells. Based on this phenomenon several works have proposed microfluidic designs to separate the suspending physiological fluid from whole in vitro blood. However, most of these studies have the aim of the complete extraction of cells from plasma which is not the case of the present study. The biomedical device that is present in this work aims to obtain a CFL with a low enough RBC propose a combination of image analysis techniques able to measure automatically the CFL thickness before and after micro-stenosis is used.
Peer review: yes
URI: http://hdl.handle.net/10198/9107
ISBN: 978-84-616-6551-8
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