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Title: Screening of antimicrobial activity of diarylamines in the 2,3,5-trimethylbenzo[b]thiophene series: a structure–activity evaluation study
Authors: Ferreira, Isabel C.F.R.
Calhelha, Ricardo C.
Estevinho, Leticia M.
Queiroz, Maria João R.P.
Keywords: Diarylamines
Antimicrobial activity
Issue Date: 2004
Publisher: Elsevier
Citation: Bioorganic & Medicinal Chemistry Letters. ISSN 0960-894X. 14:23 (2004) p. 5831-5833
Abstract: Gram positive (Bacillus cereus, B. subtilis), Gram negative (Pseudomonas aeruginosa, Escherichia coli) bacteria, and Candida albicans as a representative of fungi were used for screening the in vitro antimicrobial activity of diarylamines in the 2,3,5-trimethylbenzo[ b]thiophene series bearing different substituents, synthesized by us using the palladium-catalyzed C–N coupling methodology. The minimal inhibitory concentration (MIC) and structure–activity relationships (SARs) were evaluated.
ISSN: 0960-894X
Appears in Collections:BB - Artigos em Revistas Indexados ao ISI/Scopus

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