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|Title: ||Screening of antimicrobial activity of diarylamines in the 2,3,5-trimethylbenzo[b]thiophene series: a structure–activity evaluation study|
|Authors: ||Ferreira, Isabel C.F.R.|
Calhelha, Ricardo C.
Estevinho, Leticia M.
Queiroz, Maria João R.P.
|Issue Date: ||2004|
|Citation: ||Bioorganic & Medicinal Chemistry Letters. ISSN 0960-894X. 14:23 (2004) p. 5831-5833|
|Abstract: ||Gram positive (Bacillus cereus, B. subtilis), Gram negative (Pseudomonas aeruginosa, Escherichia coli) bacteria, and Candida albicans as a representative of fungi were used for screening the in vitro antimicrobial activity of diarylamines in the 2,3,5-trimethylbenzo[
b]thiophene series bearing different substituents, synthesized by us using the palladium-catalyzed C–N coupling
methodology. The minimal inhibitory concentration (MIC) and structure–activity relationships (SARs) were evaluated.|
|Appears in Collections:||BB - Artigos em Revistas Indexados ao ISI|
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