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Please use this identifier to cite or link to this item: http://hdl.handle.net/10198/7741

Title: Release studies of thymol and p-cymene from polylactide microcapsules
Authors: Martins, I.M.
Rodrigues, S.N.
Barreiro, M.F.
Rodrigues, A.E.
Keywords: Essential oils
Microspheres
Pharmacokinetics
Polymers
Issue Date: 2012
Publisher: ACS
Citation: Martins, I.M.; Rodrigues, S.N.; Barreiro, M.F.; Rodrigues, A.E. (2012) - Release studies of thymol and p-cymene from polylactide microcapsules. INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH. 51:35, p.11565-11571
Abstract: The objective of this work is to access the release behavior of thymol and p-cymene used as model core materials with PLA microcapsules. The microcapsules were obtained by a coacervation process developed in a previous work and present a spherical shape with mean particle size of 25 and 37 mu m for thymol and p-cymene, respectively. The results have shown that the release of thymol and p-cymene is faster in the first hour keeping almost constant in the subsequent days. The diffusion coefficient in the first hour of release was 1.99 X 10(-16) m(2)/s for thymol and 4.34 X 10(-16) m(2)/s for p-cymene. However, the diffusion was slower if considering a period of 5 days being the diffusion coefficients of 3.34 X 10(-19) m(2)/s for thymol and 3.45 X 10(-18) m(2)/s for cymene.
Peer Reviewed: yes
URI: http://hdl.handle.net/10198/7741
Appears in Collections:DTQB - Artigos em Revistas Indexados ao ISI

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