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Title: Flow of red blood cells through microchannel with a confluence
Authors: Vladimir, Leble
Lima, R.
Fernandes, Carla S.
Dias, Ricardo P.
Keywords: Red blood cells
Velocity profiles
Confocal micro-PTV
Issue Date: 2011
Citation: Vladimir, Leble; Lima, R.; Fernandes, Carla S.; Dias, Ricardo P. (2011) - Flow of red blood cells through microchannel with a confluence. In Congress on Numerical Methods in Engineering 2011. Coimbra
Abstract: Over the years micro-visualization techniques have been used to investigate in vitro blood flow through straight microchannels with dimensions close to in vivo capillaries. However, a few detailed studies have been performed in complex in vitro microvascular networks composed by diverging and converging bifurcations. The main purpose of present work is to show the application of a confocal micro-PTV system to track both flourescent particles and red blood cells (RBCs) through a rectangular polydimethysiloxane (PDMS) microchannel with a confluence. The measurements of the flow behaviour of trace particles suspended in pure water and RBCs in concentrated suspensions were performed in the surroundings of a confluence. After performing simulations with the commercial finite element software package POLYFLOW®, some experimental results were compared with the numerical ones. Experimental results for pure water were in a good agreement with numerical results. Overall, the RBCs velocities were higher than those for fluorescent particles which suggest that RBC deformability and cell-free layer formation around the apex of the confluence may play an important role on the observed deviations
Peer review: yes
Appears in Collections:DEMAT - Artigos em Proceedings Não Indexados ao ISI/Scopus

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