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Título: Influence of mobile phase composition on the preparative separation of profens by chiral liquid chromatography
Autor: Ribeiro, António E.
Pais, L.S.
Rodrigues, A.E.
Issue Date: 2005
Citação: Ribeiro, A.E.; Pais, L.S.; Rodrigues, A. (2005) - Influence of mobile phase composition on the preparative separation of profens by chiral liquid chromatography. In in ChemPor/05 9th Interantional Engineering Conference. Coimbra.
Resumo: The chirality of drugs is an important issue for the pharmaceutical industry, since the different enantiomers of a racemic drug may have distinct pharmacological activities, pharmacokinetic and pharmacodynamic effects. Because of its chiral selectivity, human body reacts with a racemic drug differently, and metabolise each enantiomer on separate pathways producing different pharmacological activity. Thus, one isomer may produce the desired therapeutic activities, while the other may be inactive or even, in worst cases, produce unwanted effects.
Arbitragem científica: yes
Appears in Collections:DTQB - Posters em Encontros Científicos Internacionais

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