Biblioteca Digital do Instituto Politécnico de Bragança   Instituto Politécnico de Bragança

Biblioteca Digital do IPB >
Escola Superior Agrária >
Produção e Tecnologia Vegetal >
PTV - Resumos em Proceedings Não Indexados ao ISI/Scopus >

Please use this identifier to cite or link to this item: http://hdl.handle.net/10198/6162

Título: Novel Hydroxy-9H-xanthen-9-ones derivatives: synthesis and bioactive properties
Autor: Santos, Clementina M.M.
Silva, Artur
Cavaleiro, José
Issue Date: 2011
Citação: Santos, Clementina M.M.; Silva, Artur; Cavaleiro, José (2011) - Novel Hydroxy-9H-xanthen-9-ones derivatives: synthesis and bioactive properties. In 23rd Internacional Congress on Heterocyclic Chemistry. Glasgow
Resumo: 9H-Xanthen-9-ones commonly referred as xanthones are a large group of natural heterocyclic compounds with significant bioactive properties (e.g. anti-inflammatory, antibacterial, antimalarial, cytotoxicity and radical scavenging activity).1 In order to explore some of these biological assessments, we developed two methodologies for the synthesis of novel hydroxylated 2,3-diarylxanthone derivatives. The first synthetic route is based on the Heck reaction of the 3-bromochromone 2 followed by aldol condensation and electrocyclisation/oxidation processes to afford the 2,3-diaryl-9H-xanthen-9-ones 1. An efficient and more general approach is the Heck reaction of 3-bromo-2-styrylchromones 3 with styrenes as olefins followed by the in situ electrocyclisation/oxidation processes.2 Pharmacological studies involving the hydroxy-9H-xanthen-9-ones 1,3 which are obtained after cleavage of the methyl group, will also be presented and discussed.
URI: http://hdl.handle.net/10198/6162
Appears in Collections:PTV - Resumos em Proceedings Não Indexados ao ISI/Scopus

Files in This Item:

File Description SizeFormat
2011 XXIII ICHC.pdf891,21 kBAdobe PDFView/Open
Statistics
FacebookTwitterDeliciousLinkedInDiggGoogle BookmarksMySpaceOrkut
Formato BibTex mendeley Endnote Logotipo do DeGóis 

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

 


© Instituto Politécnico de Bragança - Biblioteca Digital - Feedback - Statistics
Promotores do RCAAP   Financiadores do RCAAP

Fundação para a Ciência e a Tecnologia Universidade do Minho   Governo Português Ministério da Educação e Ciência PO Sociedade do Conhecimento (POSC) Portal oficial da União Europeia