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Title: Bilirubin dependent on UGT1A1 polymorphisms, hemoglobin, fasting time and body mass index
Authors: Rodrigues, Carina
Costa, Elísio
Vieira, Emília
Carvalho, João
Santos, Rosário
Rocha-Pereira, Petronila
Santos-Silva, Alice
Bronze-da-Rocha, Elsa
Keywords: Bilirubin levels
Genetic and nongenetic factors hemoglobin
Gilbert’s syndrome
Issue Date: 2011
Publisher: Lippincott Williams & Wilkins,
Citation: Rodrigues, Carina; Costa, Elísio; Vieira, Emília; Carvalho, João; Santos, Rosário; Rocha-Pereira, Petronila; Santos-Silva, Alice; Bronze-da-Rocha, Elsa; (2011) - Bilirubin dependent on UGT1A1 polymorphisms,hemoglobin, fasting time and body mass índex. American Journal of the Medical Sciences. ISSN 0002-9629. 343:2, p. 114-118.
Abstract: In humans, bilirubin levels are influenced by different factors. This study aims to evaluate the influence of several nongenetic factors (hematologic data, smoking status, alcohol intake, fasting time, physical activity, oral contraceptive therapy and caloric intake) and the genetic contribution of UGT1A1 polymorphisms for the bilirubin levels, in a cohort of young women. Hematologic data, bilirubin and screening of TA duplication in the TATA box region of the UGT1A1 gene were performed in 146 young white women. Body mass index (BMI) and body fat were determined, and a questionnaire about fasting time, smoking habits, oral contraceptive therapy, caloric intake and physical activity was performed. Participants were divided into 3 groups according to the tertiles of bilirubin levels. Subjects from the second and third tertile had significant increases in hemoglobin (Hb) concentration, hematocrit, mean cell Hb and mean cell Hb concentration compared with those in the first tertile. Red blood cell count was significantly increased in subjects in the third tertile. A significant increased frequency was found for the c.-41_-40dupTA allele in homozygosity for both second and third tertiles. Multiple linear regression analysis showed that the c.-41_-40dupTA allele, Hb, BMI and fasting hours were independent variables associated with bilirubin serum levels. Hb concentration, fasting time and BMI were identified as nongenetic causes, together with the genetic UGT1A1 polymorphisms, as the main factors associated with variations in bilirubin levels in a healthy female population.
Description: In Press
Peer review: yes
ISSN: 0002-9629
Publisher Version:,.2.aspx
Appears in Collections:DTDT - Artigos em Revistas Indexados ao ISI/Scopus

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