Biblioteca Digital do IPB >
Escola Superior Agrária >
Biologia e Biotecnologia >
BB - Resumos em Proceedings Não Indexados ao ISI >
Please use this identifier to cite or link to this item:
|Title: ||Methyl 3-amino-6-[4 or 3 or 2-(3-arylureido)phenyl]thieno[3,2-b]pyridine-2-carboxylates: synthesis and molecular modelling studies using VEGFR-2.|
|Authors: ||Peixoto, Daniela|
Froufe, Hugo J.C.
Abreu, Rui M.V.
Ferreira, Isabel C.F.R.
Queiroz, Maria João R.P.
|Issue Date: ||2011|
|Citation: ||Peixoto, Daniela; Dias, Sofia; Froufe, Hugo; Abreu, Rui M.V.; Ferreira, Isabel C.F.R.; Queiroz, Maria-João R.P. (2011) - Methyl 3-amino-6-[4 or 3 or 2-(3-arylureido)phenyl]thieno[3,2-b]pyridine-2-carboxylates: synthesis and molecular modelling studies using VEGFR-2. In 2nd Iberic Meeting on Medicinal Chemistry: G Protein-Coupled Receptors and Enzymes in Drug Discovery. Porto|
|Abstract: ||The membrane receptor tyrosine kinases (RTKs), possess both extracellular and intracellular domains and selectively catalyze the phosphorylation of tyrosine hydroxyl groups in response to binding of certain extracellular growth factors. RTK signalling pathways are normally highly regulated, yet their over-activation has been shown to promote the growth, survival, and metastasis of cancer cells, and has been associated with the progression of various human cancers. Recently some thieno[3,2-c]pyridine 1,3-diarylurea derivatives were prepared as VEGFR-2 (vascular endothelium growth factor receptor-2) inhibitors.1 Here we present the synthesis of methyl 3-amino-6-[4 or 3 or 2-(3-arylureido)phenyl]thieno[3,2-b]pyridine-2-carboxylates 2 by reaction of the methyl 3-amino-6-(4 or 3 or 2-aminophenyl)thieno[3,2-b]pyridine-2-carboxylates 1, synthesized earlier by our group,2 with arylisocyanates|
|Peer Reviewed: ||yes|
|Appears in Collections:||BB - Resumos em Proceedings Não Indexados ao ISI|
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.