Biblioteca Digital do Instituto Politécnico de Bragança   Instituto Politécnico de Bragança

Biblioteca Digital do IPB >
Escola Superior Agrária >
Biologia e Biotecnologia >
BB - Resumos em Proceedings Não Indexados ao ISI >

Please use this identifier to cite or link to this item: http://hdl.handle.net/10198/6075

Título: Methyl 3-amino-6-[4 or 3 or 2-(3-arylureido)phenyl]thieno[3,2-b]pyridine-2-carboxylates: synthesis and molecular modelling studies using VEGFR-2.
Autor: Peixoto, Daniela
Dias, Sofia
Froufe, Hugo J.C.
Abreu, Rui M.V.
Ferreira, Isabel C.F.R.
Queiroz, Maria João R.P.
Issue Date: 2011
Citação: Peixoto, Daniela; Dias, Sofia; Froufe, Hugo; Abreu, Rui M.V.; Ferreira, Isabel C.F.R.; Queiroz, Maria-João R.P. (2011) - Methyl 3-amino-6-[4 or 3 or 2-(3-arylureido)phenyl]thieno[3,2-b]pyridine-2-carboxylates: synthesis and molecular modelling studies using VEGFR-2. In 2nd Iberic Meeting on Medicinal Chemistry: G Protein-Coupled Receptors and Enzymes in Drug Discovery. Porto
Resumo: The membrane receptor tyrosine kinases (RTKs), possess both extracellular and intracellular domains and selectively catalyze the phosphorylation of tyrosine hydroxyl groups in response to binding of certain extracellular growth factors. RTK signalling pathways are normally highly regulated, yet their over-activation has been shown to promote the growth, survival, and metastasis of cancer cells, and has been associated with the progression of various human cancers. Recently some thieno[3,2-c]pyridine 1,3-diarylurea derivatives were prepared as VEGFR-2 (vascular endothelium growth factor receptor-2) inhibitors.1 Here we present the synthesis of methyl 3-amino-6-[4 or 3 or 2-(3-arylureido)phenyl]thieno[3,2-b]pyridine-2-carboxylates 2 by reaction of the methyl 3-amino-6-(4 or 3 or 2-aminophenyl)thieno[3,2-b]pyridine-2-carboxylates 1, synthesized earlier by our group,2 with arylisocyanates
Arbitragem científica: yes
URI: http://hdl.handle.net/10198/6075
Appears in Collections:BB - Resumos em Proceedings Não Indexados ao ISI

Files in This Item:

File Description SizeFormat
Poster Int. 44.pdf677,96 kBAdobe PDFView/Open
Statistics
FacebookTwitterDeliciousLinkedInDiggGoogle BookmarksMySpaceOrkut
Formato BibTex mendeley Endnote Logotipo do DeGóis 

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

 


  © Instituto Politécnico de Bragança - Biblioteca Digital - Feedback - Statistics
  Estamos no RCAAP Governo Português separator Ministério da Educação e Ciência   Fundação para a Ciência e a Tecnologia

Financiado por:

POS_C UE