Utilize este identificador para referenciar este registo: http://hdl.handle.net/10198/6075
Título: Methyl 3-amino-6-[4 or 3 or 2-(3-arylureido)phenyl]thieno[3,2-b]pyridine-2-carboxylates: synthesis and molecular modelling studies using VEGFR-2
Autor: Peixoto, Daniela
Dias, Sofia
Froufe, Hugo J.C.
Abreu, Rui M.V.
Ferreira, Isabel C.F.R.
Queiroz, Maria João R.P.
Data: 2011
Citação: Peixoto, Daniela; Dias, Sofia; Froufe, Hugo; Abreu, Rui M.V.; Ferreira, Isabel C.F.R.; Queiroz, Maria-João R.P. (2011) - Methyl 3-amino-6-[4 or 3 or 2-(3-arylureido)phenyl]thieno[3,2-b]pyridine-2-carboxylates: synthesis and molecular modelling studies using VEGFR-2. In 2nd Iberic Meeting on Medicinal Chemistry: G Protein-Coupled Receptors and Enzymes in Drug Discovery. Porto
Resumo: The membrane receptor tyrosine kinases (RTKs), possess both extracellular and intracellular domains and selectively catalyze the phosphorylation of tyrosine hydroxyl groups in response to binding of certain extracellular growth factors. RTK signalling pathways are normally highly regulated, yet their over-activation has been shown to promote the growth, survival, and metastasis of cancer cells, and has been associated with the progression of various human cancers. Recently some thieno[3,2-c]pyridine 1,3-diarylurea derivatives were prepared as VEGFR-2 (vascular endothelium growth factor receptor-2) inhibitors.1 Here we present the synthesis of methyl 3-amino-6-[4 or 3 or 2-(3-arylureido)phenyl]thieno[3,2-b]pyridine-2-carboxylates 2 by reaction of the methyl 3-amino-6-(4 or 3 or 2-aminophenyl)thieno[3,2-b]pyridine-2-carboxylates 1, synthesized earlier by our group,2 with arylisocyanates
Peer review: yes
URI: http://hdl.handle.net/10198/6075
Aparece nas colecções:BB - Resumos em Proceedings Não Indexados ao ISI/Scopus

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