Utilize este identificador para referenciar este registo: http://hdl.handle.net/10198/6054
Título: Propolis influence on erythrocyte membrane disorder (hereditary spherocytosis): a first approach
Autor: Moreira, Leandro
Dias, Teresa
Rogão, Mónica
Dias, L.G.
Silva, José Paulo
Estevinho, Leticia M.
Palavras-chave: Erythrocyte membrane
Bee products
Data: 2011
Editora: Elsevier
Citação: Moreira, Leandro; Dias, Teresa; Rogão, Mónica; Dias, Luis G.; Silva, José Paulo; Estevinho, Leticia (2011) - Propolis influence on erythrocyte membrane disorder (hereditary spherocytosis): a first approach. Food and Chemical Toxicology. ISSN 0278-6915. 49:2, p. 520-526
Resumo: Propolis is a resinous substance collected from plants by bees. Its composition depends on the vegetation, the season, and the source area. It usually contains many chemical compounds such as polyphenols, steroids and amino acids. The hereditary spherocytosis (HS) is a type of anaemia characterized by microcytic and hyperchromic red cells, spherical in shape and without central pallor. Clinically, subjects present from asymptomatic conditions to severe haemolytic anaemia. In this study it was evaluated the effect of two propolis extracts in the osmotic fragility of HS patient red blood cell (RBC) membrane. It was found that propolis decreases the erythrocytes membrane fragility, being the effect of Bornes propolis more pronounced than Fundão propolis’. This effect was related with the higher phenolic content of the former propolis. The results obtained in vitro suggest that the membrane fragility increases under oxidative stress conditions for the patient RBC’s and the protection effect of propolis is due to its antioxidant properties. These results open doors for future investigations in order to elucidate the mechanisms, identify the main compounds involved in this fragility protection of the erythrocyte membrane. This is the first work reporting an evaluation of the propolis effect in a blood disease.
Peer review: yes
URI: http://hdl.handle.net/10198/6054
ISSN: 0278-6915
Aparece nas colecções:CIMO - Artigos em Revistas Indexados ao WoS/Scopus

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