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|Title: ||New potential anti-hepatocellular carcinoma (HCC) agents: in vitro evaluation of anti-HCC activity and hepatotoxicity of 6-substituted methyl 3-aminothieno[3,2-b]pyridine-2-carboxylates and QSAR studies.|
|Authors: ||Abreu, Rui M.V.|
Queiroz, Maria João R.P.
Ferreira, Isabel C.F.R.
Calhelha, Ricardo C.
|Issue Date: ||2011|
|Citation: ||Abreu, Rui M.V.; Queiroz, Maria-João R.P.; Ferreira, Isabel C.F.R.; Calhelha, Ricardo C.; Adega, Filomena; Chaves, Raquel (2011) - New potential anti-hepatocellular carcinoma (HCC) agents: in vitro evaluation of anti-HCC activity and hepatotoxicity of 6-substituted methyl 3-aminothieno[3,2-b]pyridine-2-carboxylates and QSAR studies. In XX Porto Cancer Meeting. Drug resistance in cancer: from biology to molecular targets and drugs. Porto|
|Abstract: ||Hepatocellular carcinoma (HCC) is a major health problem with more than 660,000 new cases per year worldwide . HCC is resistant to commonly used treatments like chemotherapy and radiotherapy and new anti-HCC therapies are urgently needed. Sorafenib was the first approved small molecule against HCC and underlines the importance of identifying potential new anti-HCC drugs .
Thirty-two 6-substituted methyl 3-aminothieno[3,2-b]pyridine-2-carboxylates, previously prepared by some of us [3,4], were evaluated as potential new anti-HCC agents by studying their in vitro cell growth inhibition on human HepG2 cells, generally regarded as a good HCC model, and hepatotoxicity using a porcine liver primary cell culture (PLP1). The presence of amino groups linked to a benzene moiety on the substituent of the 6-position emerged as the key element for the anti-HCC activity.|
|Peer Reviewed: ||yes|
|Appears in Collections:||BB - Resumos em Proceedings Não Indexados ao ISI|
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